IGHMBP2 基因缺失会抑制翻译并激活综合应激反应

IF 3.3 2区生物学 Q1 BIOLOGY

Life Science Alliance Pub Date : 2024-05-21 DOI:10.26508/lsa.202302554

Jesslyn Park, Hetvee Desai, José Liboy-Lugo, Sohyun Gu, Ziad M. Jowhar, Albert Xu, S. Floor

引用次数: 0

摘要

我们研究了人类细胞缺失 IGHMBP2（一种与疾病相关的扰动）的遗传后果。依赖于 IGHMBP2 的基因表达变化包括 ATF4（一种关键的 ISR 因子）的上调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IGHMBP2 deletion suppresses translation and activates the integrated stress response

We characterized the genetic consequences of deleting IGHMBP2—a disease-relevant perturbation—in human cells. IGHMBP2-dependent gene expression changes included up-regulation of ATF4, a key ISR factor.

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来源期刊

Life Science Alliance Agricultural and Biological Sciences-Plant Science

CiteScore

5.80

自引率

2.30%

发文量

241

审稿时长

10 weeks

期刊介绍： Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.