儿童双侧前庭分裂瘤合并脑膜瘤:病例报告和文献综述

Ram Prasad Chaulagain, Yelona Shrestha, Kusha KC., Abal Baral
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引用次数: 0

摘要

脑膜瘤和前庭许旺瘤(VS)是第一和第二常见的中枢神经系统(CNS)良性肿瘤。VS 和脑膜瘤同时存在的临床情况非常罕见,尤其是在儿童患者中。本报告介绍了一例尼泊尔儿童双侧前庭许旺瘤并发脑膜瘤的病例,并概述了有关该病症的文献。 一名 15 岁的男性患者出现双侧感音神经性听力损失、癫痫发作和神经功能缺损,最终被诊断为同时患有双侧听神经瘤和脑膜瘤。患者接受了双侧前庭分裂瘤放射外科手术和脑膜瘤非手术治疗。长期随访显示症状有所改善,强调了多学科方法在处理此类复杂病例中的重要性。这些肿瘤的治疗需要根据肿瘤的特点和相关风险采取量身定制的治疗策略。 脑膜瘤和前庭分裂瘤是中枢神经系统的常见肿瘤。神经纤维瘤病 2 型(NF2)患者有可能同时患有这两种肿瘤,但在儿童中极为罕见。这些肿瘤常常同时存在,给诊断带来了挑战。诊断依赖于临床和遗传学特征,并由不同的专科医生进行多学科管理。治疗的目的是通过贝伐单抗和手术干预等方法,保护患者的功能和生活质量。放射治疗的作用仍不确定。基因检测和定期监测对早期发现和干预至关重要。 人们对听神经瘤和脑膜瘤的并发症知之甚少,报告的病例有限,病理生理机制也不清楚。需要进一步研究这些肿瘤并存的遗传和分子机制,以优化这一罕见临床实体的患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bilateral vestibular schwannoma with a cooccurring meningioma in a child: A case report and review of literature
Meningioma and Vestibular Schwannoma (VS) are the first and second most common benign Central Nervous System (CNS) tumors. The coexistence of VS and meningioma presents a rare clinical scenario, particularly in pediatric patients. This report presents a case of bilateral Vestibular Schwannoma with a cooccurring Meningioma in in a Nepali child and provides an overview of the literature on this condition. A 15-year-old male presented with bilateral sensorineural hearing loss, seizures, and neurological deficits and was ultimately diagnosed with concomitant bilateral acoustic neuroma and meningioma. The patient underwent radiosurgery for bilateral vestibular schwannoma and non-operative management of the meningioma. Long-term follow-up revealed symptomatic improvement, emphasizing the importance of a multidisciplinary approach in managing such complex cases. The management of these tumors requires tailored treatment strategies guided by tumor characteristics and associated risks. Meningioma and vestibular schwannoma are common tumors of the CNS. Their coexistence is possible in Neurofibromatosis type 2 (NF2) but is exceedingly rare in pediatric age group. The tumors, often coexisting, pose diagnostic challenges. Diagnosis relies on clinical and genetic features, with multidisciplinary management involving various specialists. Treatment aims to preserve function and quality of life, utilizing approaches such as bevacizumab and surgical intervention. The role of radiation therapy remains uncertain. Genetic testing and regular monitoring are vital for early detection and intervention. The co-occurrence of acoustic neuromas and meningiomas is poorly understood, with limited reported cases and unclear pathophysiological mechanisms. Further research into the genetic and molecular mechanisms underlying the coexistence of these tumors is needed to optimize patient outcomes in this rare clinical entity.
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