单葡萄糖基橙皮甙和单葡萄糖基芦丁对血管柔韧性的有益影响：一项随机、安慰剂对照、双盲、平行组研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-23 DOI:10.31989/ffhd.v14i5.1319

Yushi Hashizume, M. Tandia

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引用次数: 0

摘要

背景：越来越多的证据表明，摄入多酚有助于预防心血管并发症。此外，摄入多种不同的多酚化合物有望产生协同效应。然而，很少有研究对健康成年人同时摄入多酚对心血管并发症的预防效果进行研究。研究目的本研究旨在评估每天单独摄入 70 毫克单葡糖基橙皮甙（MH）或同时摄入 140 毫克单葡糖基芦丁（MR）对改善血管柔韧性的功效：这项为期 8 周的研究针对 66 名身体质量指数（BMI）相对较高且血管柔韧性较低的健康男性和女性参与者。参与者通过计算机生成的名单被随机分配到 MH 组（仅 MH）、MHMR 组（MH 和 MR 的组合）或安慰剂组（每组 n = 22）。干预期间，参与者每天服用两片 MH、MHMR 或安慰剂。结果包括血管功能指数、毛细血管流量和炎症指标。评估时间为干预4周（4w）和8周（8w）：主要结果是血流介导的扩张。在对按协议组基线时左肱-踝脉搏波速度（baPWV）≥1232.5 cm/s的参与者进行的分析中，与安慰剂组相比，MHMR 组在血流介导的扩张、血管扩张后动脉最大直径、baPWV（每条腿和两条腿的平均值）以及 8w 时的 E-选择素方面均有显著改善：这些结果表明，MH 与 MR 联合使用可对血管内皮细胞产生作用，从而改善血管柔韧性相对较低的健康成年人的血管柔韧性。(UMIN000046054).Keywords:单葡糖基橙皮甙；单葡糖基芦丁；血流介导的扩张；E-选择素；脉搏波速度；体重指数；血管柔韧性

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The beneficial effects of monoglucosyl hesperidin and monoglucosyl rutin on vascular flexibility: a randomized, placebo-controlled, double-blind, parallel-group study

Background: There is mounting evidence that the intake of polyphenols can help prevent cardiovascular complications. Furthermore, multiple intakes of different polyphenol compounds are expected to have a synergistic effect. However, few studies have examined the preventive effect of simultaneous polyphenol intake on cardiovascular complications in healthy adults. Objective: The present study aimed to evaluate the efficacy of daily intake of 70 mg of monoglucosyl hesperidin (MH) alone, or in combination with 140 mg of monoglucosyl rutin (MR), in improving vascular flexibility. Methods: This 8-week study was conducted on 66 healthy male and female participants with a relatively high body mass index (BMI) and low vascular flexibility. The participants were randomly assigned to an MH group (MH alone), MHMR group (combination of MH and MR), or placebo group by a computer-generated list (each n = 22). Participants took two tablets per day of either MH, MHMR or placebo during the intervention. Outcomes included vascular function indices, capillary flow, and inflammatory markers. Assessment points were at 4 weeks (4w) and 8 weeks (8w) of the intervention. Results: The primary outcome was flow-mediated dilation. In an analysis including participants whose left brachial-ankle pulse wave velocity (baPWV) was ≥1232.5 cm/s at baseline in the per-protocol set, the MHMR group showed significant improvement compared with the placebo group in flow-mediated dilation, maximum post-avascularization artery diameter, baPWV (each and average of both legs), and E-selectin at 8w. Conclusion: These results indicated that MH, in combination with MR, may act on vascular endothelial cells to improve vascular flexibility in healthy adults with a relatively lowvascular flexibility. (UMIN000046054). Keywords: Monoglucosyl hesperidin; Monoglucosyl rutin; flow-mediated dilation; E-selectin; pulse wave velocity, body mass index, vascular flexibility

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.