肾癌与尿液细胞外囊泡的潜在用途

IF 3.1 Q2 ONCOLOGY

Oncology Reviews Pub Date : 2024-05-23 DOI:10.3389/or.2024.1410450

Linh Nguy-Hoang Le, Javaria Munir, Eun-Bit Kim, Seongho Ryu

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引用次数: 0

摘要

肾癌是全球第 14 位最常见的癌症。肾癌局部阶段的 5 年相对生存率为 92.9%，转移阶段则降至 17.4%。目前，最准确的诊断方法是组织活检。然而，由于活检具有创伤性且费用高昂，许多患者不愿意接受活检。因此，应探索用于诊断和预后的新型生物标志物。尿液细胞外囊泡（uEVs）是尿液中携带核酸、蛋白质和脂质的小囊泡（50-200 nm）。这些 uEVs 的载体可以为监测肾脏健康提供非侵入性的替代方法。在这篇综述中，我们总结了近期有关将 uEVs 货物作为肾癌生物标记物用于诊断、预后和治疗干预的潜在用途的研究。

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Kidney Cancer and Potential Use of Urinary Extracellular Vesicles

Kidney cancer is the 14th most common cancer globally. The 5-year relative survival rate of kidney cancer at a localized stage is 92.9% and it declines to 17.4% in metastatic stage. Currently, the most accurate method of its diagnosis is tissue biopsy. However, the invasive and costly nature of biopsies makes it undesirable in many patients. Therefore, novel biomarkers for diagnosis and prognosis should be explored. Urinary extracellular vesicles (uEVs) are small vesicles (50–200 nm) in urine carrying nucleic acids, proteins and lipids as their cargos. These uEVs’ cargos can provide non-invasive alternative to monitor kidney health. In this review, we have summarized recent studies investigating potential use of uEVs’ cargos as biomarkers in kidney cancer for diagnosis, prognosis and therapeutic intervention.

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来源期刊

Oncology Reviews ONCOLOGY-

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.