脑外伤研究中的实验动物模型:方法与展望综述

Umar Faruk Saidu, I. Bulama, Andrew Onu, A. Abbas, Yusuf Sai̇du, L. S. Bilbis
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引用次数: 0

摘要

创伤性脑损伤(TBI)仍然是全球关注的一个重大公共卫生问题,需要有效的研究模型来阐明其病理生理学并开发治疗干预措施。动物模型在创伤性脑损伤研究中发挥着至关重要的作用,可为损伤机制和潜在治疗方法提供宝贵的见解。然而,由于可供选择的模型种类繁多,且各自存在优势和局限性,因此选择合适的模型可能具有挑战性。在这篇综述中,我们研究了四种常用的创伤性脑损伤动物模型:重物下坠模型、流体叩击模型、皮层冲击模型和爆炸损伤模型。每种模型都具有不同的损伤机制,使研究人员能够模拟创伤性脑损伤病理的各个方面。我们讨论了每种模型的独特优缺点,深入探讨了它们的应用以及根据研究目标和结果衡量标准选择模型的注意事项。此外,我们还强调了创伤性脑损伤建模的新方向,强调了完善和创新模型以复制人类创伤性脑损伤复杂性的重要性。通过批判性地评估和理解不同创伤性脑损伤模型的微妙之处,研究人员可以做出明智的决定,以提高创伤性脑损伤临床前研究的转化潜力,并最终改善创伤性脑损伤患者的临床治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experimental animal models in traumatic brain injury research: a comprehensive review of methods and outlook
Traumatic brain injury (TBI) remains a significant public health concern worldwide, necessitating effective research models to elucidate its pathophysiology and develop therapeutic interventions. Animal models play a crucial role in TBI research, offering valuable insights into injury mechanisms and potential treatments. However, selecting the appropriate model can be challenging due to diverse array of available options and their respective advantages and limitations. In this comprehensive review, we examine four commonly used animal models of TBI: the weight drop, fluid percussion, cortical impact, and blast injury models. Each model is characterized by distinct injury mechanisms, allowing researchers simulate various aspects of TBI pathology. We discuss the unique advantages and disadvantages of each model, providing insights into their applications and considerations for model selection based on research objectives and outcome measures. Furthermore, we highlight emerging directions in TBI modelling, emphasizing the importance of refining and innovating models to replicate the complexity of human TBI. By critically evaluating and understanding the subtlety of different TBI models, researchers can make informed decisions to enhance the translational potential of preclinical TBI research and ultimately improve clinical outcomes for TBI patients.
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