用微型和纳米级羟基磷灰石颗粒进行表面改性,增强聚(乳酸-共聚-乙醇酸)笼状结构的生物功能

IF 1.6 Q4 ENGINEERING, BIOMEDICAL
Dongbiao Chang, Siyu Li, Zhenfan Bai, Jing You, Lili Cao, Qingcao Li, Huan Tan, Yan Zheng, Feilun Ye, Jie Weng
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引用次数: 0

摘要

性能卓越的生物材料对于应对复杂的骨再生挑战至关重要。与传统的三维支架相比,可注射微球为治疗不规则骨缺损提供了新策略。作为药物、蛋白质和其他活性大分子的微载体,可生物降解聚(乳酸-共聚-乙醇酸)已得到广泛应用。将羟基磷灰石(HA)应用于聚(乳酸-共-乙醇酸)笼状结构(PLGA-CAS)的表面,可有效减少炎症,同时增强生物效应。在本研究中,我们在 PLGA-CAS 表面添加了微型和纳米羟基磷灰石颗粒,分别称为 μHA/PLGA-CAS 和 nHA/PLGA-CAS。随后,对它们的材料特性和生物效应进行了评估。在 PLGA-CAS 中加入羟基磷灰石后,表面粗糙度和亲水性增强,热稳定性提高,降解延迟。此外,μHA/PLGA-CAS 还能诱导成骨细胞前体细胞的成骨分化,而 nHA/PLGA-CAS 则能改善内皮细胞的粘附性并刺激体外血管生成分化。总之,这些研究结果表明,μHA/PLGA-CAS 和 nHA/PLGA-CAS 各具特色,具有作为微载体应用于各种生物医学领域的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Enhancing the biological functionality of poly (lactic-co-glycolic acid) cage-like structures through surface modification with micro- and nano-sized hydroxyapatite particles

Enhancing the biological functionality of poly (lactic-co-glycolic acid) cage-like structures through surface modification with micro- and nano-sized hydroxyapatite particles

Biomaterials with exceptional performance are crucial for addressing the challenges of complex bone regeneration. Compared with traditional three-dimensional scaffolds, injectable microspheres enable new strategies for the treatment of irregular bone defects. Biodegradable poly (lactic-co-glycolic acid) has found widespread applications as microcarriers of drugs, proteins, and other active macromolecules. Applied to the surface of poly (lactic-co-glycolic acid) cage-like structures (PLGA-CAS), hydroxyapatite (HA) effectively reduces inflammation while enhancing biological effects. In this study, we loaded the surface of PLGA-CAS with micro- and nano-hydroxyapatite particles, referred to as μHA/PLGA-CAS and nHA/PLGA-CAS, respectively. Subsequently, their material characteristics and biological effects were assessed. The incorporation of hydroxyapatite onto PLGA-CAS resulted in enhanced surface roughness and hydrophilicity, coupled with improved thermal stability and delayed degradation. Furthermore, μHA/PLGA-CAS induced osteogenic differentiation of osteoblast precursor cells, while nHA/PLGA-CAS improved endothelial cell adhesion and stimulated angiogenic differentiation in vitro. Collectively, these findings suggest that μHA/PLGA-CAS and nHA/PLGA-CAS, each with distinct characteristics, hold significant potential for application as microcarriers in various biomedical contexts.

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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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