Dongbiao Chang, Siyu Li, Zhenfan Bai, Jing You, Lili Cao, Qingcao Li, Huan Tan, Yan Zheng, Feilun Ye, Jie Weng
{"title":"用微型和纳米级羟基磷灰石颗粒进行表面改性,增强聚(乳酸-共聚-乙醇酸)笼状结构的生物功能","authors":"Dongbiao Chang, Siyu Li, Zhenfan Bai, Jing You, Lili Cao, Qingcao Li, Huan Tan, Yan Zheng, Feilun Ye, Jie Weng","doi":"10.1049/bsb2.12080","DOIUrl":null,"url":null,"abstract":"<p>Biomaterials with exceptional performance are crucial for addressing the challenges of complex bone regeneration. Compared with traditional three-dimensional scaffolds, injectable microspheres enable new strategies for the treatment of irregular bone defects. Biodegradable poly (lactic-co-glycolic acid) has found widespread applications as microcarriers of drugs, proteins, and other active macromolecules. Applied to the surface of poly (lactic-co-glycolic acid) cage-like structures (PLGA-CAS), hydroxyapatite (HA) effectively reduces inflammation while enhancing biological effects. In this study, we loaded the surface of PLGA-CAS with micro- and nano-hydroxyapatite particles, referred to as μHA/PLGA-CAS and nHA/PLGA-CAS, respectively. Subsequently, their material characteristics and biological effects were assessed. The incorporation of hydroxyapatite onto PLGA-CAS resulted in enhanced surface roughness and hydrophilicity, coupled with improved thermal stability and delayed degradation. Furthermore, μHA/PLGA-CAS induced osteogenic differentiation of osteoblast precursor cells, while nHA/PLGA-CAS improved endothelial cell adhesion and stimulated angiogenic differentiation in vitro. Collectively, these findings suggest that μHA/PLGA-CAS and nHA/PLGA-CAS, each with distinct characteristics, hold significant potential for application as microcarriers in various biomedical contexts.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12080","citationCount":"0","resultStr":"{\"title\":\"Enhancing the biological functionality of poly (lactic-co-glycolic acid) cage-like structures through surface modification with micro- and nano-sized hydroxyapatite particles\",\"authors\":\"Dongbiao Chang, Siyu Li, Zhenfan Bai, Jing You, Lili Cao, Qingcao Li, Huan Tan, Yan Zheng, Feilun Ye, Jie Weng\",\"doi\":\"10.1049/bsb2.12080\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Biomaterials with exceptional performance are crucial for addressing the challenges of complex bone regeneration. Compared with traditional three-dimensional scaffolds, injectable microspheres enable new strategies for the treatment of irregular bone defects. Biodegradable poly (lactic-co-glycolic acid) has found widespread applications as microcarriers of drugs, proteins, and other active macromolecules. Applied to the surface of poly (lactic-co-glycolic acid) cage-like structures (PLGA-CAS), hydroxyapatite (HA) effectively reduces inflammation while enhancing biological effects. In this study, we loaded the surface of PLGA-CAS with micro- and nano-hydroxyapatite particles, referred to as μHA/PLGA-CAS and nHA/PLGA-CAS, respectively. Subsequently, their material characteristics and biological effects were assessed. The incorporation of hydroxyapatite onto PLGA-CAS resulted in enhanced surface roughness and hydrophilicity, coupled with improved thermal stability and delayed degradation. Furthermore, μHA/PLGA-CAS induced osteogenic differentiation of osteoblast precursor cells, while nHA/PLGA-CAS improved endothelial cell adhesion and stimulated angiogenic differentiation in vitro. Collectively, these findings suggest that μHA/PLGA-CAS and nHA/PLGA-CAS, each with distinct characteristics, hold significant potential for application as microcarriers in various biomedical contexts.</p>\",\"PeriodicalId\":52235,\"journal\":{\"name\":\"Biosurface and Biotribology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-05-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12080\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biosurface and Biotribology\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1049/bsb2.12080\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosurface and Biotribology","FirstCategoryId":"1087","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1049/bsb2.12080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Enhancing the biological functionality of poly (lactic-co-glycolic acid) cage-like structures through surface modification with micro- and nano-sized hydroxyapatite particles
Biomaterials with exceptional performance are crucial for addressing the challenges of complex bone regeneration. Compared with traditional three-dimensional scaffolds, injectable microspheres enable new strategies for the treatment of irregular bone defects. Biodegradable poly (lactic-co-glycolic acid) has found widespread applications as microcarriers of drugs, proteins, and other active macromolecules. Applied to the surface of poly (lactic-co-glycolic acid) cage-like structures (PLGA-CAS), hydroxyapatite (HA) effectively reduces inflammation while enhancing biological effects. In this study, we loaded the surface of PLGA-CAS with micro- and nano-hydroxyapatite particles, referred to as μHA/PLGA-CAS and nHA/PLGA-CAS, respectively. Subsequently, their material characteristics and biological effects were assessed. The incorporation of hydroxyapatite onto PLGA-CAS resulted in enhanced surface roughness and hydrophilicity, coupled with improved thermal stability and delayed degradation. Furthermore, μHA/PLGA-CAS induced osteogenic differentiation of osteoblast precursor cells, while nHA/PLGA-CAS improved endothelial cell adhesion and stimulated angiogenic differentiation in vitro. Collectively, these findings suggest that μHA/PLGA-CAS and nHA/PLGA-CAS, each with distinct characteristics, hold significant potential for application as microcarriers in various biomedical contexts.