甲基苯丙胺使用障碍与炎症：病例对照研究

IF 1.8 4区医学 Q3 PSYCHIATRY

Psychiatry Investigation Pub Date : 2024-05-25 DOI:10.30773/pi.2023.0199

Nilifer Gürbüzer, Mustafa Can Güler, I·brahim Hakkı Tör

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引用次数: 0

摘要

甲基苯丙胺使用障碍（MUD）是一种全球性的健康问题，它损害人的健康，可能导致发病和死亡。炎症是在甲基苯丙胺使用障碍中起重要作用的一个关键过程。方法我们的目的是通过评估 MUD 成年男性患者的外周血象参数、白细胞计数、亚型及其相互之间的比率、全身免疫炎症指数（SII）、单核细胞/高密度脂蛋白（HDL）比率和人类 C 反应蛋白（CRP），揭示炎症反应与 MUD 之间的关系。我们在患者组中纳入了 76 名成年男性参与者，在对照组中纳入了 70 名成年男性参与者。我们计算了中性粒细胞/淋巴细胞比率（NLR）、单核细胞/淋巴细胞比率（MLR）、血小板/淋巴细胞比率（PLR）和嗜碱性粒细胞/淋巴细胞比率（BLR）。结果患者的白细胞（P<0.001）、血小板（P<0.001）、血小板比容（PCT）（P=0.002）、中性粒细胞（P<0.001）、单核细胞（p=0.002）、CRP（p<0.001）、NLR（p=0.001）、PLR（p=0.004）、MLR（p=0.009）、SII（p<0.001）和单核细胞/高密度脂蛋白比（p<0.001）均高于对照组。我们观察到，每日甲基苯丙胺摄入量与甲基苯丙胺吸食时间（p=0.002）、PCT（p=0.044）、中性粒细胞（p=0.021）、NLR（p=0.001）、PLR（p=0.004）、MLR（p=0.029）和SII（p<0.001）之间存在明显的正相关关系。每日甲基苯丙胺摄入量对 SII 有显著的积极影响。结果证实，在患有 MUD 的成年男性中，存在外周亚临床炎症和全身免疫炎症。

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Methamphetamine Use Disorder and Inflammation: A Case-Control Study

Objective Methamphetamine use disorder (MUD) is a global health condition that impairs a person’s health which may result in morbidity and mortality. Inflammation is a crucial process playing a vital role in MUD. For this reason, it is necessary to examine biochemical parameters for follow-up and treatment alternatives.Methods We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parameters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipoprotein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the patient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate.Results The patients’ leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units.Conclusion The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.

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来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.