沙棘（Hippophae rhamnoides, L.）果肉油可防止紫外线诱导的人体成纤维细胞损伤

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-05-25 DOI:10.1093/bbb/zbae071

Takuya Okamoto, Fumie Nakashima, Takahiro Shibata, Daisuke Mori

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引用次数: 0

摘要

沙棘果肉油（SBO）富含亲脂性物质，具有很高的营养保健和美容潜力，因此被用于美容产品中。然而，SBO 增强皮肤弹性的机制仍不清楚。因此，在本研究中，我们研究了 SBO 在紫外线（UV）照射下对正常人真皮成纤维细胞（NHDF）的抗光老化活性。经 SBO 预处理后，紫外线-B 诱导的细胞毒性和胶原降解得到明显抑制，这表明 SBO 含有抗光照老化物质。此外，SBO 的主要成分棕榈油酸（POA）通过抑制基质金属蛋白酶 1（MMP-1）的表达、抑制 p38 和 JNK 磷酸化以及核因子卡巴 B（NF-κB）的核转位，维持了经 UV-B 照射的 NHDF 的细胞活力和胶原蛋白水平。这些研究结果表明，SBO 可作为一种抗光老化剂。

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Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts

Seabuckthorn pulp oil (SBO) is used in beauty products because of its rich lipophilic substances with high nutraceutical and cosmeceutical potential. However, the mechanism through which SBO enhances skin elasticity remains unclear. Therefore, in this study, we examined the anti-photoaging activity of SBO in normal human dermal fibroblasts (NHDF) under ultraviolet (UV) irradiation. Pretreatment with SBO significantly suppressed UV-B-induced cell toxicity and collagen degradation, suggesting that SBO contains anti-photoaging substances. Further, palmitoleic acid (POA), the main component of SBO, maintained cell viability and collagen levels in UV-B-irradiated NHDF by suppressing the expression of matrix metalloproteinase 1 (MMP-1) and acted on the inhibition of p38 and JNK phosphorylation and nuclear translocation of nuclear factor-kappa B (NF-κB). These findings suggest the utility of SBO as an anti-photoaging agent.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).