Xiao-Long Shi , Shuo Chen , Guo-Dong Guo , Yun-Ling Yang , Kang-Mei Tong , Wen Cao , Lin-Lin Huang , Yan-Ru Zhang
{"title":"对局限于子宫的子宫内膜癌进行精确淋巴结活检:43 例临床病例分析","authors":"Xiao-Long Shi , Shuo Chen , Guo-Dong Guo , Yun-Ling Yang , Kang-Mei Tong , Wen Cao , Lin-Lin Huang , Yan-Ru Zhang","doi":"10.1016/j.tjog.2023.11.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To explore a precise association between tumor location and lymph node (LN) biopsy algorithm in uterine confined endometrial cancer (EC).</p></div><div><h3>Materials and methods</h3><p>Patients with EC treated in the Department of Obstetrics and Gynecology, South Branch of Fujian Provincial Hospital were included in this observational retrospective study. Based on the procedure of treatment, patients were separated to stage I (2015.07–2019.09) and stage II (2019.09–2021.9). In each stage, patients were separated to high and low-risk group by the predicted results. Patients in the high-risk group received systematic lymphadenectomy in stage I and sentinel lymph node (SLN) dissection in stage II. The efficiency of lymph node metastasis (LNM) detection rates was compared between stage I and stage II cases. Precise lymph node biopsy algorithm was also constructed based on the outcomes of stage II.</p></div><div><h3>Results</h3><p>Overall, 43 patients, 28 in stage I and 15 in stage II, were included in the study. No recurrence or death cases had been found within follow-up terms. Based on the difference in the detection efficiency of LNM (p > 0.05), there was no difference between two stages. Thus, systematic lymphadenectomy and SLN biopsy provided similar success rates. The location of tumor site was also important for deciding whether pelvic or para-aortic SLN should be sampled for LNM.</p></div><div><h3>Conclusions</h3><p>Precise SLN biopsy for EC confined to the uterus showed comparable LNM detection rate as systematic lymphadenectomy. EC location may be used to determine whether pelvic or para-aortic SLN sampling should be conducted for treatment.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1028455924000779/pdfft?md5=171723fe4d1dc2c616ea67e5421fd164&pid=1-s2.0-S1028455924000779-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Precise lymph node biopsy for endometrial cancer confined to the uterus: Analysis of 43 clinical cases\",\"authors\":\"Xiao-Long Shi , Shuo Chen , Guo-Dong Guo , Yun-Ling Yang , Kang-Mei Tong , Wen Cao , Lin-Lin Huang , Yan-Ru Zhang\",\"doi\":\"10.1016/j.tjog.2023.11.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To explore a precise association between tumor location and lymph node (LN) biopsy algorithm in uterine confined endometrial cancer (EC).</p></div><div><h3>Materials and methods</h3><p>Patients with EC treated in the Department of Obstetrics and Gynecology, South Branch of Fujian Provincial Hospital were included in this observational retrospective study. Based on the procedure of treatment, patients were separated to stage I (2015.07–2019.09) and stage II (2019.09–2021.9). In each stage, patients were separated to high and low-risk group by the predicted results. Patients in the high-risk group received systematic lymphadenectomy in stage I and sentinel lymph node (SLN) dissection in stage II. The efficiency of lymph node metastasis (LNM) detection rates was compared between stage I and stage II cases. Precise lymph node biopsy algorithm was also constructed based on the outcomes of stage II.</p></div><div><h3>Results</h3><p>Overall, 43 patients, 28 in stage I and 15 in stage II, were included in the study. No recurrence or death cases had been found within follow-up terms. Based on the difference in the detection efficiency of LNM (p > 0.05), there was no difference between two stages. Thus, systematic lymphadenectomy and SLN biopsy provided similar success rates. The location of tumor site was also important for deciding whether pelvic or para-aortic SLN should be sampled for LNM.</p></div><div><h3>Conclusions</h3><p>Precise SLN biopsy for EC confined to the uterus showed comparable LNM detection rate as systematic lymphadenectomy. EC location may be used to determine whether pelvic or para-aortic SLN sampling should be conducted for treatment.</p></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1028455924000779/pdfft?md5=171723fe4d1dc2c616ea67e5421fd164&pid=1-s2.0-S1028455924000779-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1028455924000779\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1028455924000779","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
摘要
摘要] 目的 探讨子宫局限性子宫内膜癌(EC)肿瘤位置与淋巴结活检算法之间的精确关联。根据治疗过程,将患者分为Ⅰ期(2015.07-2019.09)和Ⅱ期(2019.09-2021.9)。在每个阶段,根据预测结果将患者分为高风险组和低风险组。高风险组患者在I期接受系统淋巴结切除术,在II期接受前哨淋巴结(SLN)清扫术。比较了 I 期和 II 期病例的淋巴结转移(LNM)检出率。研究共纳入 43 例患者,其中 28 例为 I 期,15 例为 II 期。随访期间未发现复发或死亡病例。根据 LNM 检测效率的差异(P> 0.05),两期之间没有差异。因此,系统性淋巴腺切除术和 SLN 活检术的成功率相似。肿瘤部位的位置对于决定盆腔还是主动脉旁 SLN 取样检测 LNM 也很重要。EC的位置可用于确定应进行盆腔还是主动脉旁SLN取样治疗。
Precise lymph node biopsy for endometrial cancer confined to the uterus: Analysis of 43 clinical cases
Objective
To explore a precise association between tumor location and lymph node (LN) biopsy algorithm in uterine confined endometrial cancer (EC).
Materials and methods
Patients with EC treated in the Department of Obstetrics and Gynecology, South Branch of Fujian Provincial Hospital were included in this observational retrospective study. Based on the procedure of treatment, patients were separated to stage I (2015.07–2019.09) and stage II (2019.09–2021.9). In each stage, patients were separated to high and low-risk group by the predicted results. Patients in the high-risk group received systematic lymphadenectomy in stage I and sentinel lymph node (SLN) dissection in stage II. The efficiency of lymph node metastasis (LNM) detection rates was compared between stage I and stage II cases. Precise lymph node biopsy algorithm was also constructed based on the outcomes of stage II.
Results
Overall, 43 patients, 28 in stage I and 15 in stage II, were included in the study. No recurrence or death cases had been found within follow-up terms. Based on the difference in the detection efficiency of LNM (p > 0.05), there was no difference between two stages. Thus, systematic lymphadenectomy and SLN biopsy provided similar success rates. The location of tumor site was also important for deciding whether pelvic or para-aortic SLN should be sampled for LNM.
Conclusions
Precise SLN biopsy for EC confined to the uterus showed comparable LNM detection rate as systematic lymphadenectomy. EC location may be used to determine whether pelvic or para-aortic SLN sampling should be conducted for treatment.