Meidi Xiong , Yuping Cheng , Ying Luo , Chao Fang , Hongmei Yao , Qianqian Liu , Fang Lu , Xuan Li , Ziying Bie , Jinbing Bai , Chunhua Zhang
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引用次数: 0
摘要
本纵向研究旨在探讨皮质醇和希望水平对来自武汉市三个中心的552名乳腺癌患者的癌症复发恐惧(FCR)和生活质量(QOL)的影响。方法 一项由武汉市三个中心的552名乳腺癌患者参与的纵向研究采用了中文版的癌症进展恐惧问卷-简表(FoP-Q-SF)、赫斯希望指数(HHI)和癌症治疗功能评估-乳腺(FACT-B)量表。皮质醇水平每天测量三次,数据纵向收集三次。使用 SPSS 26.0 和 Mplus 8.3 进行数据分析,采用交叉滞后法构建纵向路径模型。在与希望水平相关的结果中发现了一个重要的中介模型。具体来说,FCR 预测了希望水平的下降(β = -0.163,p < 0.001),而希望水平的下降又导致了整体 QOL 的下降(β = -0.078,p < 0.001),中介效应占 10.34%。尽管不同时间点的 FCR、皮质醇水平和 QOL 之间存在相关性,但进一步的分析表明,皮质醇水平在二者之间并未表现出中介效应(95% 置信区间:-0.002 至 0.001)。考虑到希望是 FCR 和 QOL 之间的重要中介,本研究提出了优化乳腺癌患者 QOL 的潜在干预策略。
The impact of fear of cancer recurrence on the quality of life of breast cancer patients: A longitudinal study of the mediation effect of cortisol and hope
Objective
This longitudinal study sought to explore the impact of cortisol and hope levels on Fear of Cancer Recurrence (FCR) and Quality of Life (QOL) in a cohort of 552 breast cancer patients from three centers in Wuhan City.
Method
A longitudinal study involving 552 breast cancer patients from three centers in Wuhan City utilized Chinese versions of the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the Herth Hope Index (HHI), and the Functional Assessment of Cancer Therapy-Breast (FACT-B) scale. Cortisol levels were measured thrice daily, and data was collected longitudinally three times. Data analysis was conducted using SPSS 26.0 and Mplus 8.3, employing a longitudinal path model constructed via the cross-lagged method.
Results
The results showed there were significant correlations between FCR, cortisol levels, and QOL at different time points. A significant mediating model was found with outcomes related to hope levels. Specifically, FCR predicted a decrease in hope levels (β = −0.163, p < 0.001), which in turn led to a decrease in overall QOL (β = −0.078, p < 0.001), with a mediation effect accounting for 10.34%. Although there were correlations between FCR, cortisol levels, and QOL at different time points, further analysis revealed that cortisol levels did not exhibit a mediating effect between the two (95% confidence interval: −0.002 to 0.001).
Conclusion
This study demonstrated there were significant correlations among FCR, QOL, and hope levels. Considering hope as a crucial mediator between FCR and QOL, potential intervention strategies for optimizing the QOL of breast cancer patients are proposed.
期刊介绍:
The European Journal of Oncology Nursing is an international journal which publishes research of direct relevance to patient care, nurse education, management and policy development. EJON is proud to be the official journal of the European Oncology Nursing Society.
The journal publishes the following types of papers:
• Original research articles
• Review articles