Birui Jin , Chuyao Zhang , Chuan Ma , Huiling Yin , Siyu Li , Zhiguo Du , Guoxu Zhao , Huimei Huang , Zedong Li
{"title":"提高基于光学探针的床旁检测生物传感器性能的创新策略和方法","authors":"Birui Jin , Chuyao Zhang , Chuan Ma , Huiling Yin , Siyu Li , Zhiguo Du , Guoxu Zhao , Huimei Huang , Zedong Li","doi":"10.1016/j.trac.2024.117775","DOIUrl":null,"url":null,"abstract":"<div><p>Optical probe-based biosensors (OPBs) have proven instrumental in human health monitoring. The growing portability and miniaturization of OPBs have rendered them cost-effective and user-friendly, presenting great potential for the advancement of point-of-care testing (POCT) platforms. To further expand their applications, ongoing efforts have been made to enhance their detection performance, particularly focusing on sensitivity. This review provides a comprehensive overview on existing OPBs in POCT and summarizes their underlying detection principles. Additionally, this review highlights four strategies and approaches for enhancing the performance of OPBs: optimizing target-capturing capability, improving the conversion efficiency of biological signals to optical signals, enhancing the separation ability of signal separation system, and optimizing the signal recognition ability of the reader. By focusing on these strategies, this review explores the potential of optimized OPBs in expanding their applications across various human health-related domains.</p></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":11.8000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Innovative strategies and approaches for enhancing performance in optical probe-based biosensors for point-of-care testing\",\"authors\":\"Birui Jin , Chuyao Zhang , Chuan Ma , Huiling Yin , Siyu Li , Zhiguo Du , Guoxu Zhao , Huimei Huang , Zedong Li\",\"doi\":\"10.1016/j.trac.2024.117775\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Optical probe-based biosensors (OPBs) have proven instrumental in human health monitoring. The growing portability and miniaturization of OPBs have rendered them cost-effective and user-friendly, presenting great potential for the advancement of point-of-care testing (POCT) platforms. To further expand their applications, ongoing efforts have been made to enhance their detection performance, particularly focusing on sensitivity. This review provides a comprehensive overview on existing OPBs in POCT and summarizes their underlying detection principles. Additionally, this review highlights four strategies and approaches for enhancing the performance of OPBs: optimizing target-capturing capability, improving the conversion efficiency of biological signals to optical signals, enhancing the separation ability of signal separation system, and optimizing the signal recognition ability of the reader. By focusing on these strategies, this review explores the potential of optimized OPBs in expanding their applications across various human health-related domains.</p></div>\",\"PeriodicalId\":439,\"journal\":{\"name\":\"Trends in Analytical Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":11.8000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Analytical Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165993624002589\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993624002589","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Innovative strategies and approaches for enhancing performance in optical probe-based biosensors for point-of-care testing
Optical probe-based biosensors (OPBs) have proven instrumental in human health monitoring. The growing portability and miniaturization of OPBs have rendered them cost-effective and user-friendly, presenting great potential for the advancement of point-of-care testing (POCT) platforms. To further expand their applications, ongoing efforts have been made to enhance their detection performance, particularly focusing on sensitivity. This review provides a comprehensive overview on existing OPBs in POCT and summarizes their underlying detection principles. Additionally, this review highlights four strategies and approaches for enhancing the performance of OPBs: optimizing target-capturing capability, improving the conversion efficiency of biological signals to optical signals, enhancing the separation ability of signal separation system, and optimizing the signal recognition ability of the reader. By focusing on these strategies, this review explores the potential of optimized OPBs in expanding their applications across various human health-related domains.
期刊介绍:
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.