{"title":"确定新药靶点以实现药物再利用的现有方法。","authors":"Khushal Khambhati, Vijai Singh","doi":"10.1016/bs.pmbts.2024.03.020","DOIUrl":null,"url":null,"abstract":"<p><p>Currently, millions of drugs and their licence have been expired or will be expiring in near future. Therefore, existing USFDA approved drug can be used for treating another disease. The above-mentioned approach falls under the category of drug repurposing. Drug repurposing is an alternative strategy for finding new applications of existing USFDA approved drugs. Identification of a novel drug target is one of the go to way for drug repurposing so that new therapeutic applications of USFDA approved drugs could be determined. Recent advances in computational biology and bioinformatics can help to accelerate the same. Drug repurposing can save time and resource as compared to discovery of an entirely new drug molecule. In this chapter, we explore different strategies for discovery of a novel drug target and its uses for drug repurposing to treat disease.</p>","PeriodicalId":49280,"journal":{"name":"Progress in Molecular Biology and Translational Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Current approaches in identification of a novel drug targets for drug repurposing.\",\"authors\":\"Khushal Khambhati, Vijai Singh\",\"doi\":\"10.1016/bs.pmbts.2024.03.020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Currently, millions of drugs and their licence have been expired or will be expiring in near future. Therefore, existing USFDA approved drug can be used for treating another disease. The above-mentioned approach falls under the category of drug repurposing. Drug repurposing is an alternative strategy for finding new applications of existing USFDA approved drugs. Identification of a novel drug target is one of the go to way for drug repurposing so that new therapeutic applications of USFDA approved drugs could be determined. Recent advances in computational biology and bioinformatics can help to accelerate the same. Drug repurposing can save time and resource as compared to discovery of an entirely new drug molecule. In this chapter, we explore different strategies for discovery of a novel drug target and its uses for drug repurposing to treat disease.</p>\",\"PeriodicalId\":49280,\"journal\":{\"name\":\"Progress in Molecular Biology and Translational Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Molecular Biology and Translational Science\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.pmbts.2024.03.020\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Molecular Biology and Translational Science","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.pmbts.2024.03.020","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/4 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Current approaches in identification of a novel drug targets for drug repurposing.
Currently, millions of drugs and their licence have been expired or will be expiring in near future. Therefore, existing USFDA approved drug can be used for treating another disease. The above-mentioned approach falls under the category of drug repurposing. Drug repurposing is an alternative strategy for finding new applications of existing USFDA approved drugs. Identification of a novel drug target is one of the go to way for drug repurposing so that new therapeutic applications of USFDA approved drugs could be determined. Recent advances in computational biology and bioinformatics can help to accelerate the same. Drug repurposing can save time and resource as compared to discovery of an entirely new drug molecule. In this chapter, we explore different strategies for discovery of a novel drug target and its uses for drug repurposing to treat disease.
期刊介绍:
Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.