中心视网膜缺失后的视觉训练可限制白质结构退化:磁共振成像研究。

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES
Anna Kozak, Marco Ninghetto, Michał Wieteska, Michał Fiedorowicz, Marlena Wełniak-Kamińska, Bartosz Kossowski, Ulf T Eysel, Lutgarde Arckens, Kalina Burnat
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引用次数: 0

摘要

背景:眼底黄斑变性是导致失明的常见原因,全世界有 8% 的人受到影响。在双侧视网膜中央受损的成年猫身上,我们探索了运动感知训练能否限制视觉系统退化的可能性。我们评估了视觉训练如何影响行为表现和白质结构。最近,我们提出了(Kozak 等人,载于 Transl Vis Sci Technol 10:9,2021 年)一种针对低视力患者的新运动敏锐度测试,通过同时感知形状和运动来实现全面的视野功能评估。在此,我们将该测试作为为期 10 周的运动感知训练的最后一步:结果:我们将猫分为三组:仅视网膜缺损组和两组训练组,即视网膜缺损训练组和对照组。行为数据显示,受过训练的视网膜病变猫在运动任务中更胜一筹,即使难度仅取决于敏锐度。7 视网膜病变前后在 5 个不同的时间点进行了 T-MRI 扫描,随后进行了基于 Fixel 的分析和分数各向异性分析。在视网膜病变的猫中,与未接受过训练的猫相比,训练使dLGN、尾状核和海马的Fixel-Based分析指标下降的百分比更局部、更低。在运动敏感区域 V5/PMLS,视网膜缺损的未训练猫和训练猫的纤维密度显著下降的程度相当,两组均高达 40%。唯一不受中心视网膜缺失影响的皮层区域是 V5/PMLS 区域。在其他视觉 ROI 中,未经训练的视网膜病变组的各向异性分数值随着时间的推移而增加,而视网膜病变的训练组的各向异性分数值则有所下降,并保持在与训练对照组相似的水平:总体而言,我们的磁共振成像结果显示,在诱导视网膜中央缺失后不久进行运动训练对白质结构有稳定作用。我们建议,对低视力患者进行早期运动敏锐度训练,针对完整和活跃的视网膜周边进行训练,可促进大脑的可塑性过程,从而改善视力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Visual training after central retinal loss limits structural white matter degradation: an MRI study.

Background: Macular degeneration of the eye is a common cause of blindness and affects 8% of the worldwide human population. In adult cats with bilateral lesions of the central retina, we explored the possibility that motion perception training can limit the associated degradation of the visual system. We evaluated how visual training affects behavioral performance and white matter structure. Recently, we proposed (Kozak et al. in Transl Vis Sci Technol 10:9, 2021) a new motion-acuity test for low vision patients, enabling full visual field functional assessment through simultaneous perception of shape and motion. Here, we integrated this test as the last step of a 10-week motion-perception training.

Results: Cats were divided into three groups: retinal-lesioned only and two trained groups, retinal-lesioned trained and control trained. The behavioral data revealed that trained cats with retinal lesions were superior in motion tasks, even when the difficulty relied only on acuity. 7 T-MRI scanning was done before and after lesioning at 5 different timepoints, followed by Fixel-Based and Fractional Anisotropy Analysis. In cats with retinal lesions, training resulted in a more localized and reduced percentage decrease in Fixel-Based Analysis metrics in the dLGN, caudate nucleus and hippocampus compared to untrained cats. In motion-sensitive area V5/PMLS, the significant decreases in fiber density were equally strong in retinal-lesioned untrained and trained cats, up to 40% in both groups. The only cortical area with Fractional Anisotropy values not affected by central retinal loss was area V5/PMLS. In other visual ROIs, the Fractional Anisotropy values increased over time in the untrained retinal lesioned group, whereas they decreased in the retinal lesioned trained group and remained at a similar level as in trained controls.

Conclusions: Overall, our MRI results showed a stabilizing effect of motion training applied soon after central retinal loss induction on white matter structure. We propose that introducing early motion-acuity training for low vision patients, aimed at the intact and active retinal peripheries, may facilitate brain plasticity processes toward better vision.

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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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