使用光致变色共价抑制剂在细胞内化学构建可光开关的 CENP-E。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-06-12 DOI:10.1039/d4ob00647j

Kazuya Matsuo , Shusuke Yamaoka , Tomonori Waku , Akio Kobori

引用次数: 0

摘要

研究人员开发了一种针对有丝分裂运动蛋白--中心粒相关蛋白E（CENP-E）的芳基吡唑共价抑制剂。利用这种可光开关抑制剂，在细胞中化学构建了可光开关的 CENP-E，从而能够在光照下局部控制有丝分裂细胞的分裂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

In-cell chemical construction of a photoswitchable CENP-E using a photochromic covalent inhibitor†

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In-cell chemical construction of a photoswitchable CENP-E using a photochromic covalent inhibitor†

An arylazopyrazole-based covalent inhibitor targeting the mitotic motor protein of centromere-associated protein E (CENP-E) was developed. Using this photoswitchable inhibitor, a photoswitchable CENP-E was chemically constructed in cells, which enabled to local control of mitotic cell division with light illumination.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.