异腈脂肽的生物合成

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2024-05-23 DOI:10.1016/j.cbpa.2024.102470

Kaimin Jia , Helen Sun , Yiyan Zhou , Wenjun Zhang

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引用次数: 0

摘要

从放线菌中发现的异腈脂肽因其迷人的生物合成途径以及与包括结核分枝杆菌在内的许多人类病原体的毒力相关而受到广泛关注。具体来说，属于非血红素铁（II）和α-酮戊二酸依赖性二氧酶的新一类异腈生成酶的鉴定引起了多个研究小组对其催化机理的兴趣。在此，我们总结了最近有关链霉菌和分枝杆菌异腈脂肽生物合成的研究。本综述讨论了有关参与该途径的核心酶和修饰酶以及异腈代谢酶的最新研究。

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Biosynthesis of isonitrile lipopeptides

Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α-ketoglutarate dependent dioxygenases has intrigued several research groups to investigate their catalytic mechanism. Here we summarize the recent studies on the biosynthesis of isonitrile lipopeptides from Streptomyces and Mycobacterium. The latest research on the core and tailoring enzymes involved in the pathway as well as the isonitrile metabolic enzymes are discussed in this review.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.