{"title":"外周血嗜酸性粒细胞在慢性阻塞性肺病患者临床检测中的 Meta 分析。","authors":"Chunmei Zhang, Jie Song, Jinxiang Wang","doi":"10.5114/ada.2024.139124","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Meta-analysis was used to investigate the relationship between peripheral blood eosinophil (EOS) levels, clinical characteristics, and prognosis in chronic obstructive pulmonary disease (COPD)patients in previous literature.</p><p><strong>Aim: </strong>To analyse the correlation between peripheral blood EOS levels and clinical characteristics and prognosis of patients with COPD using meta-analysis.</p><p><strong>Material and methods: </strong>In databases such as PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wan Fang Data, literature related to the clinical characteristics or prognosis of COPD patients with high-level EOS published before July 2023 was searched for meta-analysis.</p><p><strong>Results: </strong>Through computer search and screening, 29 articles were ultimately included. The meta-analysis results showed that compared to conventional EOS levels, COPD patients with high EOS levels had a lower proportion of GOLD III-IV grade patients (OR = 00.78, 95% CI (0.68, 0.88), <i>p</i> < 0.001), lower CAT scores (OR = -1.01, 95% CI (-1.75, -0.28), <i>p</i> = 0.007), shorter hospital stay (OR = -1.33, 95% CI (-1.52, -1.14), <i>p</i> < 0.001), and lower mortality rate (OR = 0.53, 95% CI (0.42, 0.66), <i>p</i> < 0.001). The readmission rate was low (OR = 0.40, 95% CI (0.33, 0.48), <i>p</i> < 0.001), and there was no statistically significant difference in FEV1%pred (OR = -0.55, 95% CI (-1.33, 0.23), <i>p</i> = 0.17), higher FEV1/FVC values (OR = -0.45, 95% CI (-1.08, 0.18), <i>p</i> = 0.160), and mechanical ventilation usage rate (OR = 0.89, 95% CI (0.65, 1.21), <i>p</i> = 0.450) among COPD patients with different EOS levels.</p><p><strong>Conclusions: </strong>The levels of peripheral blood EOS in COPD patients are related to lung function, respiratory symptoms, etc.; Moreover, COPD patients with high-level EOS have shorter hospital stays, lower mortality and readmission rates. Therefore, ESO can be used as an auxiliary indicator for clinical symptom diagnosis of COPD patients and as an auxiliary indicator for predicting prognosis.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110220/pdf/","citationCount":"0","resultStr":"{\"title\":\"Meta-analysis of peripheral blood eosinophils in clinical testing of chronic obstructive pulmonary disease patients.\",\"authors\":\"Chunmei Zhang, Jie Song, Jinxiang Wang\",\"doi\":\"10.5114/ada.2024.139124\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Meta-analysis was used to investigate the relationship between peripheral blood eosinophil (EOS) levels, clinical characteristics, and prognosis in chronic obstructive pulmonary disease (COPD)patients in previous literature.</p><p><strong>Aim: </strong>To analyse the correlation between peripheral blood EOS levels and clinical characteristics and prognosis of patients with COPD using meta-analysis.</p><p><strong>Material and methods: </strong>In databases such as PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wan Fang Data, literature related to the clinical characteristics or prognosis of COPD patients with high-level EOS published before July 2023 was searched for meta-analysis.</p><p><strong>Results: </strong>Through computer search and screening, 29 articles were ultimately included. The meta-analysis results showed that compared to conventional EOS levels, COPD patients with high EOS levels had a lower proportion of GOLD III-IV grade patients (OR = 00.78, 95% CI (0.68, 0.88), <i>p</i> < 0.001), lower CAT scores (OR = -1.01, 95% CI (-1.75, -0.28), <i>p</i> = 0.007), shorter hospital stay (OR = -1.33, 95% CI (-1.52, -1.14), <i>p</i> < 0.001), and lower mortality rate (OR = 0.53, 95% CI (0.42, 0.66), <i>p</i> < 0.001). The readmission rate was low (OR = 0.40, 95% CI (0.33, 0.48), <i>p</i> < 0.001), and there was no statistically significant difference in FEV1%pred (OR = -0.55, 95% CI (-1.33, 0.23), <i>p</i> = 0.17), higher FEV1/FVC values (OR = -0.45, 95% CI (-1.08, 0.18), <i>p</i> = 0.160), and mechanical ventilation usage rate (OR = 0.89, 95% CI (0.65, 1.21), <i>p</i> = 0.450) among COPD patients with different EOS levels.</p><p><strong>Conclusions: </strong>The levels of peripheral blood EOS in COPD patients are related to lung function, respiratory symptoms, etc.; Moreover, COPD patients with high-level EOS have shorter hospital stays, lower mortality and readmission rates. Therefore, ESO can be used as an auxiliary indicator for clinical symptom diagnosis of COPD patients and as an auxiliary indicator for predicting prognosis.</p>\",\"PeriodicalId\":54595,\"journal\":{\"name\":\"Postepy Dermatologii I Alergologii\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11110220/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Postepy Dermatologii I Alergologii\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/ada.2024.139124\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/4/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Postepy Dermatologii I Alergologii","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/ada.2024.139124","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/24 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
摘要
简介：目的：采用荟萃分析法研究慢性阻塞性肺疾病（COPD）患者外周血嗜酸性粒细胞（EOS）水平、临床特征和预后之间的关系：在PubMed、Embase、Web of Science、Cochrane Library、中国知网（CNKI）、万方数据等数据库中，检索2023年7月之前发表的与高EOS水平COPD患者临床特征或预后相关的文献，进行荟萃分析：通过计算机检索和筛选，最终纳入 29 篇文章。荟萃分析结果显示，与常规EOS水平相比，EOS水平高的COPD患者中GOLD III-IV级患者比例较低（OR = 00.78，95% CI (0.68，0.88)，P < 0.001），CAT 评分较低（OR = -1.01, 95% CI (-1.75, -0.28)，P = 0.007），住院时间较短（OR = -1.33, 95% CI (-1.52, -1.14), P < 0.001），死亡率较低（OR = 0.53, 95% CI (0.42, 0.66)，P < 0.001）。再入院率低（OR = 0.40，95% CI (0.33，0.48)，P < 0.001），FEV1%pred（OR = -0.55，95% CI (-1.33，0.23)，P = 0.17）、更高的FEV1/FVC值（OR = -0.45，95% CI (-1.08，0.18)，p = 0.160）和机械通气使用率（OR = 0.89，95% CI (0.65，1.21)，p = 0.450）在不同EOS水平的COPD患者中差异无统计学意义：结论：慢性阻塞性肺病患者外周血 EOS 水平与肺功能、呼吸道症状等有关；此外，EOS 水平高的慢性阻塞性肺病患者住院时间短，死亡率和再入院率低。因此，ESO可作为慢性阻塞性肺病患者临床症状诊断的辅助指标和预测预后的辅助指标。
Meta-analysis of peripheral blood eosinophils in clinical testing of chronic obstructive pulmonary disease patients.
Introduction: Meta-analysis was used to investigate the relationship between peripheral blood eosinophil (EOS) levels, clinical characteristics, and prognosis in chronic obstructive pulmonary disease (COPD)patients in previous literature.
Aim: To analyse the correlation between peripheral blood EOS levels and clinical characteristics and prognosis of patients with COPD using meta-analysis.
Material and methods: In databases such as PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wan Fang Data, literature related to the clinical characteristics or prognosis of COPD patients with high-level EOS published before July 2023 was searched for meta-analysis.
Results: Through computer search and screening, 29 articles were ultimately included. The meta-analysis results showed that compared to conventional EOS levels, COPD patients with high EOS levels had a lower proportion of GOLD III-IV grade patients (OR = 00.78, 95% CI (0.68, 0.88), p < 0.001), lower CAT scores (OR = -1.01, 95% CI (-1.75, -0.28), p = 0.007), shorter hospital stay (OR = -1.33, 95% CI (-1.52, -1.14), p < 0.001), and lower mortality rate (OR = 0.53, 95% CI (0.42, 0.66), p < 0.001). The readmission rate was low (OR = 0.40, 95% CI (0.33, 0.48), p < 0.001), and there was no statistically significant difference in FEV1%pred (OR = -0.55, 95% CI (-1.33, 0.23), p = 0.17), higher FEV1/FVC values (OR = -0.45, 95% CI (-1.08, 0.18), p = 0.160), and mechanical ventilation usage rate (OR = 0.89, 95% CI (0.65, 1.21), p = 0.450) among COPD patients with different EOS levels.
Conclusions: The levels of peripheral blood EOS in COPD patients are related to lung function, respiratory symptoms, etc.; Moreover, COPD patients with high-level EOS have shorter hospital stays, lower mortality and readmission rates. Therefore, ESO can be used as an auxiliary indicator for clinical symptom diagnosis of COPD patients and as an auxiliary indicator for predicting prognosis.
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