大麻二酚对耐力锻炼主观反应的影响:随机对照试验

IF 4.1 2区 医学 Q1 SPORT SCIENCES
Danielle McCartney, Christopher Irwin, Zeeta Bawa, Blake Palmer, Ayshe Sahinovic, Nathan Delang, Gregory R Cox, Ben Desbrow, Namson S Lau, Iain S McGregor
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引用次数: 0

摘要

背景:众所周知,运动可以改善健康。然而,运动可能令人不快,往往会引起负面情绪或 "影响"。据报道,大麻二酚(CBD)是大麻植物中的一种无毒成分,可增强运动的主观体验,特别是在训练有素的人进行固定强度的耐力活动时。在此,我们研究了 CBD 在更符合生态学原理的条件下对运动主观反应的影响,即在进行自定步调耐力活动的休闲活动者中:方法:2023 年 7 月 17 日至 8 月 28 日,我们在格里菲斯大学进行了一项随机、双盲、安慰剂对照、交叉试验。格里菲斯大学学习运动营养学的学生应邀参加了试验,符合条件的志愿者年龄≥ 18 岁,能够进行耐力锻炼。参与者在完成绕室外田径跑道(400 米,合成跑道)自定节奏的 25 圈(10 公里)跑步前 90 分钟,服用安慰剂或 150 毫克 CBD(两粒软胶囊)。主要研究结果是运动过程中的情绪价值,在完成第 6、12、18 和 24 圈时使用 "感觉量表 "进行评估;以及积极和消极情绪,在基线、跑前和跑后使用 "积极和消极情绪表 "进行评估。此外,还评估了运动乐趣、动机和自我效能、"跑步兴奋 "的核心特征(即兴奋、疼痛、焦虑、镇静)、感觉到的消耗和跑步时间:52名参与者被随机选中,51名被纳入最终样本(n = 22名女性;22 [21-25]岁)。运动会引起负面情绪(即在进行运动时)并增加疼痛。CBD 并没有抵消这两种反应。事实上,CBD 对测量的任何结果都没有显著影响。相比之下,运动一旦完成,就会增加积极情绪,减少消极情绪和焦虑:结论:CBD(150 毫克,口服)似乎不会增强娱乐性活跃人群自我节奏耐力锻炼的主观体验。结论:CBD(150 毫克,口服)似乎不会增强娱乐性活跃人群自我节奏耐力锻炼的主观体验,但也不会损害这种体验。这些研究结果表明,在运动条件下使用 CBD 是安全的,而且不太可能妨碍参加体育活动。我们的研究还再次证实了运动对增强情绪的强大作用:2023年5月31日在澳大利亚新西兰临床试验注册中心(www.anzctr.org.au)注册(试验编号:ACRN12623000593639)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Cannabidiol on Subjective Responses to Endurance Exercise: A Randomised Controlled Trial.

Background: Exercise is known to improve health. However, it can be unpleasant, often inducing negative feelings, or 'affect'. Cannabidiol (CBD), a non-intoxicating constituent of the cannabis plant, has been reported to enhance the subjective experience of exercise; specifically, in trained individuals performing fixed-intensity endurance activity. Here, we investigated the effects of CBD on subjective responses to exercise under more ecologically valid conditions; namely, in recreationally active individuals performing self-paced endurance activity.

Methods: A randomised, double-blind, placebo-controlled, crossover trial was conducted at Griffith University between July 17 and August 28, 2023. Griffith University students studying sports nutrition were invited to take part, with eligible volunteers ≥ 18 years of age and able to perform endurance exercise. Participants ingested placebo or 150 mg CBD in two soft-gel capsules 90 min before completing a self-paced 25-lap (10 km) run around an outdoor athletics track (400 m, synthetic). The primary outcomes were affective valence during exercise, assessed on completion of laps 6, 12, 18 and 24 using the 'Feelings Scale', and positive and negative affect, assessed at baseline, pre-run and post-run using the 'Positive and Negative Affect Schedule'. Exercise enjoyment, motivation and self-efficacy, the core features of the 'runner's high' (i.e., euphoria, pain, anxiety, sedation), perceived exertion and run time were also assessed.

Results: Fifty-two participants were randomised and 51 were included in the final sample (n = 22 female; 22 [21-25] years). Exercise induced negative affect (i.e., at the time of undertaking) and increased pain. CBD did not counteract either response. In fact, CBD had no significant effects on any of the outcomes measured. In contrast, exercise, once completed, increased positive affect, and decreased negative affect and anxiety.

Conclusions: CBD (150 mg, oral) does not appear to enhance the subjective experience of self-paced endurance exercise in recreationally active individuals. Nor, however, does it appear to compromise it. These findings suggest that CBD use is safe under exercise conditions and unlikely to impede physical activity participation. Our study also reaffirms the powerful mood-enhancing effects of exercise.

Trial registration: Registered with the Australian New Zealand Clinical Trials Registry ( www.anzctr.org.au ) on May 31, 2023 (Trial ID: ACTRN12623000593639).

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来源期刊
Sports Medicine - Open
Sports Medicine - Open SPORT SCIENCES-
CiteScore
7.00
自引率
4.30%
发文量
142
审稿时长
13 weeks
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