慢性便秘的药物治疗。

Hoyoung Wang, Jung Won Lee
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引用次数: 0

摘要

慢性便秘是一种会影响生活质量的常见疾病,全球发病率为 14%,韩国为 16.5%。排便费力、粪便坚硬、排便不尽感、肛门直肠堵塞感以及手动排便是慢性便秘的相关症状。另一方面,与改变生活方式、生物反馈或手术等非药物治疗相比,通常被称为泻药的药物是治疗便秘的基本方法。遗憾的是,确定便秘的药物治疗是否恰当的需求仍未得到满足。因此,在韩国的实际临床情况中,是否充分考虑了泻药的适应症和副作用,并将其作为便秘的主要治疗方式,存在很多弊端。对于已排除器质性病因,且对最初的非药物疗法(如膳食纤维摄入量和运动)无反应的患者,一般建议将泻药作为下一步治疗方法。泻药可分为散结性泻药、渗透性泻药、刺激性泻药和其他新型泻药。另一方面,便秘的发生有不同的机制,适当的用药是最关键的。因此,本研究者撰写了这篇综述,讨论韩国治疗慢性便秘的适当药物策略。此外,本文还对特殊患者群体的适当药物治疗方案提出了建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacologic Treatment of Chronic Constipation.

Chronic constipation is a common disease that can impair the quality of life, with a prevalence of 14% globally and 16.5% in South Korea. Straining, hard stools, the sensation of incomplete evacuation, the sensation of anorectal blockage, and manual maneuvers to facilitate defecation are the related symptoms of chronic constipation. On the other hand, medications commonly referred to as laxatives are the essentials of treatment for constipation compared to non-pharmacological treatment, such as lifestyle modifications, biofeedback, or surgery. Unfortunately, there is still an unmet need to determine if pharmacological treatment for constipation is being administered appropriately. Therefore, there are many disadvantages as to whether the indications and side effects of laxatives are adequately considered and prescribed as the primary treatment modality for constipation in a real clinical situation in Korea. Laxatives are generally recommended as the next step for patients in whom organic causes have been excluded and have not responded to initial non-pharmacologic therapies such as dietary fiber intake and exercise. Laxatives can be classified as bulk-forming laxatives, osmotic laxatives, stimulant laxatives, and other novel laxatives. On the other hand, there are distinct mechanisms underlying constipation, and appropriate administration is the most decisive. Therefore, the present investigators prepared this review to discuss appropriate pharmacological strategies for chronic constipation in Korea. Moreover, this paper also includes suggestions for appropriate pharmacological treatment options for special patient populations.

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