用阿弗利贝赛治疗 DME 和 RVO 患者的近视力以及与 NEI VFQ-25 问卷的相关性。

IF 1.9 Q2 OPHTHALMOLOGY
Zuzana Anwarzai Sulavikova, Zuzana Sustykevicova, Marek Kacerik, Vladimir Krasnik
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引用次数: 0

摘要

背景:本研究旨在评估糖尿病黄斑水肿(DME)和视网膜静脉闭塞(RVO)引起的黄斑水肿患者接受阿弗利百普治疗后的近距离和远距离视力(VA)及其与美国国家眼科研究所视觉功能问卷(NEI VFQ-25)结果的相关性:在这项前瞻性研究中,我们纳入了87名被诊断为DME(61人)和RVO(26人)的患者,他们接受了aflibercept治疗,并随访至第8次注射。第1次、第2次、第3次、第4次、第6次和第8次注射时检查近视力,第1次、第4次和第8次注射aflibercept时患者填写NEI VFQ-25:所有眼睛基线时的平均近视力为 0.89 ± 0.12 logMAR。每次注射后,近视力都有显著改善;第 4 次(0.70 ± 0.19;p = 0.000)和第 8 次(0.60 ± 0.19;p = 0.000)。基线时,NEI VFQ-25 总分的平均值为 71 ± 14%,第 8 次注射时提高到 81 ± 13%(p = 0.000)。近视力分量表的得分增长最为明显(+ 20 ± 14%,p = 0.000)。DME组和RVO组在问卷调查和近视力结果上没有明显的统计学差异:结论:阿弗利百普治疗第8次后,近视力显著提高了4行logMAR视力表。在治疗期间,最初得分最低的近视力问卷分量表显示了最大的进步。这凸显了近视和阅读能力对 DME 和 RVO 患者的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Near vision in patients with DME and RVO treated with aflibercept and correlation with NEI VFQ-25 questionnaire.

Background: The aim of this study is to evaluate near and distance visual acuity (VA) and their correlation with the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) outcomes in patients with diabetic macular edema (DME) and macular edema due to retinal vein occlusion (RVO) treated with aflibercept.

Methods: In this prospective study, we included 87 eyes of patients diagnosed with DME (n = 61) and RVO (n = 26), who received aflibercept treatment and were followed until the 8th injection. Near VA was examined on the 1st, 2nd, 3rd, 4th, 6th, and 8th injection, and patients completed the NEI VFQ-25 on the 1st, 4th, and 8th aflibercept injection.

Results: The mean near VA at baseline in all eyes was 0.89 ± 0.12 logMAR. With every administration, there was a statistically significant improvement; on the 4th (0.70 ± 0.19; p = 0.000) and the 8th application (0.60 ± 0.19; p = 0.000). At baseline, the mean NEI VFQ-25 total score was 71 ± 14%, and improved to 81 ± 13% (p = 0.000) on the 8th injection. The most significant score gain was recorded in the near VA subscale (+ 20 ± 14%, p = 0.000). There was no statistically significant difference between DME and RVO group in the questionnaire or near VA outcomes.

Conclusion: Aflibercept treatment resulted in a remarkable improvement of near vision by 4 lines of logMAR optotype after the 8th application. The near vision questionnaire subscale, initially scoring the lowest, exhibited the greatest gain during the treatment period. This underscores the importance of near vision and reading ability for patients with DME and RVO.

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来源期刊
CiteScore
3.50
自引率
4.30%
发文量
81
审稿时长
19 weeks
期刊介绍: International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities
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