刺猬信号在晚期癌症类型中的治疗潜力。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Richa Singh, Anindita Ray
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引用次数: 0

摘要

在本章中,我们试图阐明刺猬信号通路在肿瘤发生中的相关性。在此,我们描述了不同类型的刺猬信号(规范和非规范),并重点介绍了其在肿瘤发生过程中采用的不同机制(突变驱动、自分泌、旁分泌和反向旁分泌)。我们讨论了刺猬信号在局部和晚期癌症类型中调节细胞增殖、侵袭和上皮细胞向间质转化的作用,这些作用在基于临床前和临床模型的不同研究中均有报道。我们还特别探讨了刺猬信号在侵袭性神经内分泌肿瘤中的作用。我们还详细阐述了显示癌症中刺猬信号抑制剂治疗相关性的研究。此外,我们还简要讨论了刺猬信号元件与其他信号通路串扰的证据,以及肿瘤异质性导致的治疗耐药性。总之,我们试图对刺猬信号在各种癌症,特别是侵袭性肿瘤类型中的治疗潜力的研究进行汇编,并对哪些方面存在不足和需要进一步研究提出展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic potential of hedgehog signaling in advanced cancer types.

In this chapter, we have made an attempt to elucidate the relevance of hedgehog signaling pathway in tumorigenesis. Here, we have described different types of hedgehog signaling (canonical and non-canonical) with emphasis on the different mechanisms (mutation-driven, autocrine, paracrine and reverse paracrine) it adopts during tumorigenesis. We have discussed the role of hedgehog signaling in regulating cell proliferation, invasion and epithelial-to-mesenchymal transition in both local and advanced cancer types, as reported in different studies based on preclinical and clinical models. We have specifically addressed the role of hedgehog signaling in aggressive neuroendocrine tumors as well. We have also elaborated on the studies showing therapeutic relevance of the inhibitors of hedgehog signaling in cancer. Evidence of the crosstalk of hedgehog signaling components with other signaling pathways and treatment resistance due to tumor heterogeneity have also been briefly discussed. Together, we have tried to put forward a compilation of the studies on therapeutic potential of hedgehog signaling in various cancers, specifically aggressive tumor types with a perspective into what is lacking and demands further investigation.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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