将褪黑素与右美托咪定结合使用可改善大鼠的麻醉效果。

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Laboratory Animals Pub Date : 2024-06-01 Epub Date: 2024-05-23 DOI:10.1177/00236772231163211

Joaquín Cogo Pagella, María F Rodríguez, Fabricio Frisina, Claudio O Cervino

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引用次数: 0

摘要

褪黑素（ML）和右美托咪定（DM）被单独用作麻醉前用药或人类和实验动物的麻醉剂。在本研究中，我们旨在研究这两种药物联合使用的麻醉特性。通过观察大鼠的行为表现并记录麻醉持续时间和深度，评估了 ML（50 和 100 毫克/千克）和 DM（50 和 100 微克/千克）几种组合的麻醉效果。根据反射的消失和恢复情况确定了五个麻醉间隔。在测试剂量下，每种单独的药物都不能诱导适当的麻醉效果，而 ML50 + DM100、ML100 + DM50 和 ML100 + DM100 组合则能使手术麻醉间隔时间达到 60 至 360 分钟。总之，我们的研究结果表明，使用 ML 可以减少 DM 的剂量，从而降低这种 α2-受体激动剂不必要的麻醉效果。

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Combining melatonin with dexmedetomidine improves anesthesia in rats.

Melatonin (ML) and dexmedetomidine (DM) are used separately as anesthetic premedication or as an anesthetic in humans and laboratory animals. In this study, we aimed to investigate the anesthetic properties of both drugs combined. The anesthetic effects of several combinations of ML (50 and 100 mg/kg) and DM (50 and 100 μg/kg) were evaluated in rats by observing behavioral manifestations and recording the duration and depth of anesthesia. Five anesthetic intervals were established according to the loss and recovery of reflexes. While each individual drug did not induce an appropriate anesthetic effect at the tested doses, ML50 + DM100, ML100 + DM50 and ML100 + DM100 combinations resulted in surgical anesthesia intervals of 60 to 360 min. Together, our results point that the use of ML allows to decrease the dose of DM, reducing the unwanted anesthetic effects of this α₂-agonist.

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来源期刊

Laboratory Animals 生物-动物学

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.