Wikstroemia chamaedaphne 树叶和枝条中的化学成分及其对潜伏 HIV 活性的激活作用。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-22 DOI:10.1080/10286020.2024.2355479

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引用次数: 0

摘要

从 Wikstroemia chamaedaphne Meisn 的叶片和枝条中纯化并鉴定了一种新化合物，命名为针叶素 B（1），以及 14 种已知化合物。通过分析光谱和 HRESIMS 数据，阐明了它们的化学结构。首次从这种植物中分离出了化合物 2、3、5、7-9、11 和 13。所有化合物都对 NH2 细胞进行了细胞毒性和激活潜伏 HIV 活性的检测。结果表明，所有化合物在 10.0 μM 的浓度下都不会产生细胞毒性，化合物 1、9-11 显示出微弱的激活活性，激活倍数分别为 4.88、7.14、5.3 和 6.97。

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Chemical constituents from the leaves and branches of Wikstroemia chamaedaphne with their activation of latent HIV activities

A new compound, named coniferin B (1), and fourteen known compounds were purified and identified from the leaves and branches of Wikstroemia chamaedaphne Meisn. Their chemical structures were elucidated through analyzing spectroscopic and HRESIMS data. Compounds 2, 3, 5, 7–9, 11, and 13 were isolated from this plant for the first time. All compounds were assayed for cytotoxicity and activation of latent HIV activity on NH2 cells. The results showed that all compounds did not produce cytotoxicity at 10.0 μM and compounds 1, 9–11 showed weak activating activity with activation folds of 4.88, 7.14, 5.3, and 6.97, respectively.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.