不要将 "非 COVID-19 "冠状病毒疾病误诊为 COVID-19。

IF 1.3 Q3 PEDIATRICS
Kam Lun Hon, Alexander K C Leung, Paul K S Chan, Su Yun Qian, Kin Tak Wong
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引用次数: 0

摘要

背景:COVID-19 全球大流行是由一种新型冠状病毒(SARS-CoV-2)引起的,随后成为一种地方性传染病。COVID 是世界卫生组织对冠状病毒疾病的首字母缩写:我们在此报告了三例可能被误诊为 COVID-19 的冠状病毒疾病病例。根据自制的快速抗原检测(RAT),所有这些家庭都报告曾感染过 COVID-19,并完成了一段时间的家庭隔离。在本次报告中,一名患儿曾因 RSV 引起哮喘发作,一名患儿曾患诺如病毒性胃炎,另一名患儿曾感染弯曲杆菌和大肠杆菌。在这些患者中,通过 PCR 分别发现了 NL63、OC43 和 229E:讨论:七种人类冠状病毒可导致包括儿童在内的传染病。通过聚合酶链式反应(PCR)检测和快速抗原检测(RAT)诊断冠状病毒疾病可能会产生混淆和问题。有些 RAT 是抗原荧光免疫测定(FIA),针对单克隆抗体检测病毒核壳蛋白。另一些则以非核壳蛋白为目标。有可能出现假阳性。如果标本的抗原水平低于检测限,也有可能出现假阴性。RAT 检测结果通常会在 6 到 7 天内保持阳性,但也有可能在 2 周内保持阳性。COVID-19 诊断可能会造成污名化。PCR 检测是检测 COVID-19 的高灵敏度 "黄金标准",但它也能检测出非感染者的非感染性病毒核酸片段,并可能长期呈阳性。在非感染者变成感染者后的几周到几个月内,检测结果都可能呈阳性:结论:本文介绍的病例除感染 COVID-19 外,还感染了其他冠状病毒疾病。冠状病毒疾病可由 SARS-CoV-2 以外的冠状病毒变种引起。在这些疾病中存在与其他病原体的合并感染。对非 COVID-19 疾病进行 PCR 检测有助于准确诊断这些疾病和呼吸道合并感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
"Non-COVID-19" Coronavirus Diseases Not to be Misdiagnosed as COVID-19.

Background: The COVID-19 global pandemic was caused by a novel coronavirus (SARS-CoV-2), which then became an endemic infection. COVID refers to the World Health Organization's coined acronym for coronavirus disease.

Case presentation: We have, herein, reported three cases of coronavirus diseases that could have been misdiagnosed as COVID-19. All of these families reported previous COVID-19 infection based on self-administered Rapid Antigen Testing (RAT) and completed a period of home isolation. In the current presentation, one child had an RSV-associated asthma attack, one had norovirus gastritis, and another had an infection with Campylobacter and E. coli. NL63, OC43, and 229E, respectively, were found by PCR in these patients.

Discussion: Seven human coronaviruses cause infectious diseases, including in children. Confusion and issues associated with coronavirus disease diagnosis by Polymerase Chain Reaction (PCR) testing and Rapid Antigen Test (RAT) may arise. Some RATs are Antigen Fluorescent Immunoassays (FIA) that target monoclonal antibodies for the detection of viral nucleocapsid protein. Others target the non-nucleocapsid proteins. False positivity is possible. False negativity is also possible if the specimen's antigen level is below the test's detection limit. RAT results usually remain positive for 6 to 7 days, but they may stay positive as long as 2 weeks. Stigmatization with the COVID-19 diagnosis may occur. The PCR test is a highly sensitive 'gold standard' for the detection of COVID-19, but it can also detect non-infectious individuals' fragmented non-infectious viral nucleic acids, and could be positive for a long period. An individual may be tested positive for a few weeks to months after the individual becomes non-infectious.

Conclusion: The cases presented here had coronavirus diseases other than COVID-19. Coronavirus diseases can be caused by coronavirus variants other than SARS-CoV-2. Co-infections with other pathogens are present in these diseases. PCR testing of non-COVID-19 diseases may help in the accurate diagnosis of these ailments and respiratory co-infections.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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