溶质细胞溶酶体功能障碍导致与年龄有关的睾丸退化

IF 31 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Olivia Tysoe
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引用次数: 0

摘要

晚发型性腺功能减退症(LOH)是一种与年龄有关的疾病,影响着 2-6% 的 40 岁男性。LOH是睾丸产生的睾酮减少的结果,可导致疲劳、性功能障碍以及对代谢性和退行性疾病的易感性增加。对来自两名健康年轻供体(SCY)和两名LOH患者(SCLOH)的原代Sertoli细胞系进行测序后发现,与SCY相比,SCLOH中溶酶体酸化基因下调,用pH敏感染料成像证实,SCLOH的溶酶体酸度严重不足。具有这些缺陷的 Sertoli 细胞被命名为 phago/auto-lysosomal dysregulated (PALD) Sertoli 细胞。"周说:"这项分析表明,Sertoli细胞溶酶体酸化异常导致脂滴积累和促炎因子分泌,是睾丸老化的一个关键特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sertoli cell lysosomal dysfunction drives age-related testicular degeneration

Sertoli cell lysosomal dysfunction drives age-related testicular degeneration
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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