从盐肤木叶中提取的三种新的酚苷

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-05-21 DOI:10.1016/j.phytol.2024.05.002

Xin Chen , Zhengxiang Tong , Rongtao Li , Jianguo Zeng

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引用次数: 0

摘要

3-hydroxy-5-methylphenol 1-O-β-D-(6′-O-cinnamoyl)-glucopyranoside (1), 3-hydroxy-5-methylphenol 1-O-β-D-(6′-O-p-hydroxycinnamoyl)-glucopyranoside (2)、3-hydroxy-5-methylphenol 1-O-β-D-(6′-O-p-hydroxybenzoyl)-glucopyranoside (3)与 7 个已知化合物（4-10）一起从 Rhus chinensis Mill 的叶子中分离出来。这些化合物的结构是在大量核磁共振光谱和高分辨率质谱分析的基础上阐明的。在分离出的化合物中，丁香苷（4）、槲皮素（5）和没食子酸乙酯（6）在 LPS 诱导的 RAW264.7 细胞中表现出适度的一氧化氮生成，IC50 值分别为 21.29 ± 0.54、34.26 ± 2.09 和 42.59 ± 0.11 μM，与阳性对照 L-NMMA（一氧化氮合酶抑制剂，IC50 为 38.41 ± 0.32 μM）相比。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Three new phenolic glycosides from Rhus chinensis leaves

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Three new phenolic glycosides from Rhus chinensis leaves

Three new phenolic glycosides, including 3-hydroxy-5-methylphenol 1-O-β-D-(6′-O-cinnamoyl)-glucopyranoside (1), 3-hydroxy-5-methylphenol 1-O-β-D-(6′-O-p-hydroxycinnamoyl)-glucopyranoside (2), 3-hydroxy-5-methylphenol 1-O-β-D-(6′-O-p-hydroxybenzoyl)-glucopyranoside (3), were isolated from the leaves of Rhus chinensis Mill, together with seven known compounds (4-10). Their structures were elucidated on the basis of extensive NMR spectral and high resolution mass spectrometry analysis. Among the isolated compounds, butein (4), quercetin (5), and ethyl gallate (6) exhibited moderate NO production in RAW264.7 cells induced by LPS with IC₅₀ values of 21.29 ± 0.54, 34.26 ± 2.09 and 42.59 ± 0.11 μM, compared with postive control L-NMMA (a nitric oxide synthase inhibitor, IC₅₀ 38.41 ± 0.32 μM).

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.