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对 TLR 配体进行精确的纳米级图案化，以改进癌症免疫疗法。

IF 4.3 Q1 BIOCHEMICAL RESEARCH METHODS
Cell Reports Methods Pub Date : 2024-05-20 DOI:10.1016/j.crmeth.2024.100782
Chung Yi Tseng, Farshad Murtada, Leo Y T Chou
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引用次数: 0

摘要

在最近一期的《自然-纳米技术》（Nature Nanotechnology）杂志上，Zeng 等人报告说，在 DNA 折纸纳米粒子上排列具有特定纳米级间距的免疫刺激 CpG 分子可增强 Th1 极化免疫反应。这些结果突出表明，佐剂的空间呈现是优化癌症疫苗疗效、安全性和耐受性的一种设计策略。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Precision nanoscale patterning of TLR ligands for improved cancer immunotherapy.

In a recent issue of Nature Nanotechnology, Zeng et al. report that arraying immuno-stimulatory CpG molecules with specific nanoscale spacing on DNA origami nanoparticles enhanced Th1-polarized immune responses. These results highlight spatial presentation of adjuvants as a design strategy to optimize cancer vaccine efficacy, safety, and tolerability.

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来源期刊
Cell Reports Methods
Cell Reports Methods Chemistry (General), Biochemistry, Genetics and Molecular Biology (General), Immunology and Microbiology (General)
CiteScore
3.80
自引率
0.00%
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0
审稿时长
111 days
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