重新审视电离辐射暴露对缺血性心脏病的反剂量-分量效应：最新研究的启示。

IF 2.5 3区医学 Q2 BIOLOGY

Radiation research Pub Date : 2024-07-01 DOI:10.1667/RADE-00230.1

Lydia B Zablotska, Mark P Little, Nobuyuki Hamada

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引用次数: 0

摘要

在过去二十年中，有新的证据表明，电离辐射照射可能与心血管疾病（CVD），尤其是缺血性心脏病（IHD）的风险升高有关。在一些受辐照群体中观察到了过高的心血管疾病风险，低、高辐射剂量和剂量率下的风险估计值基本相似。2014年，我们在本期杂志上首次报道了加拿大透视队列研究（Canadian Fluoroscopy Cohort Study）中，当辐射剂量在一段较长的时间内投放时，IHD死亡风险明显升高（剂量-分次反向效应）。在此，我们回顾了目前有关辐照剂量分馏效应的证据，讨论了对辐射防护政策的潜在影响，并提出了该领域的进一步研究方向。

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Revisiting an Inverse Dose-Fractionation Effect of Ionizing Radiation Exposure for Ischemic Heart Disease: Insights from Recent Studies.

Over the last two decades, there has been emerging evidence suggesting that ionizing radiation exposures could be associated with elevated risks of cardiovascular disease (CVD), particularly ischemic heart disease (IHD). Excess CVD risks have been observed in a number of exposed groups, with generally similar risk estimates both at low and high radiation doses and dose rates. In 2014, we reported for the first time significantly higher risks of IHD mortality when radiation doses were delivered over a protracted period of time (an inverse dose-fractionation effect) in the Canadian Fluoroscopy Cohort Study. Here we review the current evidence on the dose-fractionation effect of radiation exposure, discuss potential implication for radiation protection policies and suggest further directions for research in this area.

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来源期刊

Radiation research 医学-核医学

CiteScore

5.10

自引率

8.80%

发文量

179

审稿时长

1 months

期刊介绍： Radiation Research publishes original articles dealing with radiation effects and related subjects in the areas of physics, chemistry, biology and medicine, including epidemiology and translational research. The term radiation is used in its broadest sense and includes specifically ionizing radiation and ultraviolet, visible and infrared light as well as microwaves, ultrasound and heat. Effects may be physical, chemical or biological. Related subjects include (but are not limited to) dosimetry methods and instrumentation, isotope techniques and studies with chemical agents contributing to the understanding of radiation effects.