估计老年人认知能力的颈动脉-股动脉脉搏波速度评分:托莱多健康老龄化研究的结果。

IF 5.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY
GeroScience Pub Date : 2024-12-01 Epub Date: 2024-05-22 DOI:10.1007/s11357-024-01189-x
Fabio A Quiñónez Bareiro, José A Carnicero, Ana Alfaro Acha, Cristina Rosado Artalejo, María C Grau Jimenez, Leocadio Rodriguez Mañas, Francisco J García García
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引用次数: 0

摘要

与衰老相关的血管壁变化会影响不同器官的功能;为此,我们评估了用颈动脉-股动脉脉搏波速度(cf-PWV)测量的动脉僵化如何调节:基础认知能力和随访期间认知能力的变化。我们开展了一项基于人群的前瞻性队列研究,从托莱多健康老龄化研究中获得了 1581 名年龄大于 65 岁的参与者。我们选择了第二波(2011-2013 年)的参与者进行横断面分析。前瞻性分析选取了在第三波(2015-2017 年)中也进行了认知评估的参与者。动脉僵硬度通过 cf-PWV 进行评估。多变量分段回归模型用于评估 cf-PWV 评分与基础神经心理评估评分之间的关系,以及随访期间神经心理评估评分的变化。横断面分析表明,随着 cf-PWV 在 cf-PWV(5- 13-18)范围内的增长,观察到总短期记忆、自由长期记忆和总长期记忆有所下降。前瞻性分析表明,在 cf-PWV(> 13-18)范围内,随着 cf-PWV 的增加,认知功能在 7 分钟测试、物体辨认、即时记忆和短期记忆以及孔钉测试中逐渐恶化,而在 cf-PWV(5- 13-18)范围内,随着 cf-PWV 的增加,认知功能在 7 分钟测试、物体辨认、即时记忆和短期记忆以及孔钉测试中逐渐恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Carotid-femoral pulse wave velocity score, an estimator of cognitive performance in the elderly: results from the Toledo Study for Healthy Aging.

Carotid-femoral pulse wave velocity score, an estimator of cognitive performance in the elderly: results from the Toledo Study for Healthy Aging.

Ageing-related changes in the vascular wall influence the function of different organs; for this reason, we assessed how arterial stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) modulates: the basal cognitive performance and the change in cognitive performance over the follow-up time. We developed a prospective, population-based cohort study with 1581 participants aged > 65 years were obtained from the Toledo Study for Healthy Aging. Participants from the second wave (2011-2013) were selected for the cross-sectional analysis. Those who also performed the cognitive assessment in the third wave (2015-2017) were selected for the prospective analysis. Arterial stiffness was evaluated by cf-PWV. Multivariate segmented regression models were used to evaluate the association between cf-PWV scores and basal neuropsychological evaluation scores and change of neuropsychological evaluation scores along follow-up. Cross-sectional analysis showed that as cf-PWV grew within the cf-PWV (5- < 10) category an improvement was observed in 7-min test, free short-term memory, and hole peg test. Furthermore, in the cf-PWV (> 13-18) category a decrease was observed in total short-term memory, free long-term memory, and total long-term memory. Prospective analysis showed a progressive worsening of cognitive function as cf-PWV increases within the cf-PWV (> 13-18) category in 7-min test, object denomination, immediate and short-term memory, and hole peg test, while in the cf-PWV (5- < 10) category, there was observed a decrease in Cumulative Executive Dysfunction Index score and short-term memory. In conclusion, a higher cf-PWV score is associated with worse cognitive performance, and with a worse evolution, reinforcing the need to plan interventions to delay arterial stiffness and its consequences.

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来源期刊
GeroScience
GeroScience Medicine-Complementary and Alternative Medicine
CiteScore
10.50
自引率
5.40%
发文量
182
期刊介绍: GeroScience is a bi-monthly, international, peer-reviewed journal that publishes articles related to research in the biology of aging and research on biomedical applications that impact aging. The scope of articles to be considered include evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.
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