Victoria Virginia Beeks, Souzana Achilleos, Annalisa Quattrocchi, Chryso Th Pallari, Elena Critselis, Pascale Salameh, Mohammad Reza Rahmanian Haghighi, Jose Manuel Rodriguez-Llanes, Giuseppe Ambrosio, Andreas Artemiou, John Gabel, Catherine Marie Bennett, Joseph Cuthbertson, Claudia Zimmermann, Eva Susanna Schernhammer, Antonio José Leal Costa, Luciana Freire de Carvalho, Jackeline Christiane Pinto Lobato, Maria Athanasiadou, Julia Alison Critchley, Lucy Pollyanna Goldsmith, Levan Kandelaki, Natalya Glushkova, Kairat Davletov, Yuliya Semenova, Ivan Erzen, Olesia Verstiuk, Dimos Alekkou, Antonis Polemitis, Andreas Charalambous, Christiana A Demetriou
{"title":"C-MOR 联合体 12 个国家 COVID-19 大流行期间（2020-2021 年）的特定病因超额死亡率。","authors":"Victoria Virginia Beeks, Souzana Achilleos, Annalisa Quattrocchi, Chryso Th Pallari, Elena Critselis, Pascale Salameh, Mohammad Reza Rahmanian Haghighi, Jose Manuel Rodriguez-Llanes, Giuseppe Ambrosio, Andreas Artemiou, John Gabel, Catherine Marie Bennett, Joseph Cuthbertson, Claudia Zimmermann, Eva Susanna Schernhammer, Antonio José Leal Costa, Luciana Freire de Carvalho, Jackeline Christiane Pinto Lobato, Maria Athanasiadou, Julia Alison Critchley, Lucy Pollyanna Goldsmith, Levan Kandelaki, Natalya Glushkova, Kairat Davletov, Yuliya Semenova, Ivan Erzen, Olesia Verstiuk, Dimos Alekkou, Antonis Polemitis, Andreas Charalambous, Christiana A Demetriou","doi":"10.1007/s44197-024-00242-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study investigated cause-specific mortality rates in 12 countries during the COVID-19 pandemic in 2020 and 2021.</p><p><strong>Methods: </strong>We collected weekly cause-specific mortality data from respiratory disease, pneumonia, cardiovascular disease (CVD) and cancer from national vital statistic databases. We calculated excess mortality for respiratory disease (excluding COVID-19 codes), pneumonia, and CVD in 2020 and 2021 by comparing observed weekly against expected mortality based on historical data (2015-2019), accounting for seasonal trends. We used multilevel regression models to investigate the association between country-level pandemic-related variables and cause-specific mortality.</p><p><strong>Results: </strong>Significant reductions in cumulative mortality from respiratory disease and pneumonia were observed in 2020 and/or 2021, except for Georgia, Northern Ireland, Kazakhstan, and Ukraine, which exhibited excess mortality for one or both causes. Australia, Austria, Cyprus, Georgia, and Northern Ireland experienced excess cumulative CVD mortality in 2020 and/or 2021. Australia, Austria, Brazil, Cyprus, Georgia, Northern Ireland, Scotland and Slovenia, experienced increased crude cumulative cancer mortality during 2020 and/or 2021 compared to previous years. Among pandemic-related variables, reported COVID-19 incidence was negatively associated with increased cancer mortality, excess respiratory, (2020) and pneumonia (2021) mortality, and positively associated with respiratory and CVD mortality (2021). Stringency of control measures were negatively associated with excess respiratory disease, CVD, and increased cancer mortality (2021).</p><p><strong>Conclusions: </strong>This study provides evidence of substantial excess mortality from CVD, and notable reductions in respiratory disease and pneumonia in both years across most countries investigated. Our study also highlights the beneficial impact of stringent control measures in mitigating excess mortality from most causes in 2021.</p>","PeriodicalId":15796,"journal":{"name":"Journal of Epidemiology and Global Health","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176135/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cause-Specific Excess Mortality During the COVID-19 Pandemic (2020-2021) in 12 Countries of the C-MOR Consortium.\",\"authors\":\"Victoria Virginia Beeks, Souzana Achilleos, Annalisa Quattrocchi, Chryso Th Pallari, Elena Critselis, Pascale Salameh, Mohammad Reza Rahmanian Haghighi, Jose Manuel Rodriguez-Llanes, Giuseppe Ambrosio, Andreas Artemiou, John Gabel, Catherine Marie Bennett, Joseph Cuthbertson, Claudia Zimmermann, Eva Susanna Schernhammer, Antonio José Leal Costa, Luciana Freire de Carvalho, Jackeline Christiane Pinto Lobato, Maria Athanasiadou, Julia Alison Critchley, Lucy Pollyanna Goldsmith, Levan Kandelaki, Natalya Glushkova, Kairat Davletov, Yuliya Semenova, Ivan Erzen, Olesia Verstiuk, Dimos Alekkou, Antonis Polemitis, Andreas Charalambous, Christiana A Demetriou\",\"doi\":\"10.1007/s44197-024-00242-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study investigated cause-specific mortality rates in 12 countries during the COVID-19 pandemic in 2020 and 2021.</p><p><strong>Methods: </strong>We collected weekly cause-specific mortality data from respiratory disease, pneumonia, cardiovascular disease (CVD) and cancer from national vital statistic databases. We calculated excess mortality for respiratory disease (excluding COVID-19 codes), pneumonia, and CVD in 2020 and 2021 by comparing observed weekly against expected mortality based on historical data (2015-2019), accounting for seasonal trends. We used multilevel regression models to investigate the association between country-level pandemic-related variables and cause-specific mortality.</p><p><strong>Results: </strong>Significant reductions in cumulative mortality from respiratory disease and pneumonia were observed in 2020 and/or 2021, except for Georgia, Northern Ireland, Kazakhstan, and Ukraine, which exhibited excess mortality for one or both causes. Australia, Austria, Cyprus, Georgia, and Northern Ireland experienced excess cumulative CVD mortality in 2020 and/or 2021. Australia, Austria, Brazil, Cyprus, Georgia, Northern Ireland, Scotland and Slovenia, experienced increased crude cumulative cancer mortality during 2020 and/or 2021 compared to previous years. Among pandemic-related variables, reported COVID-19 incidence was negatively associated with increased cancer mortality, excess respiratory, (2020) and pneumonia (2021) mortality, and positively associated with respiratory and CVD mortality (2021). Stringency of control measures were negatively associated with excess respiratory disease, CVD, and increased cancer mortality (2021).</p><p><strong>Conclusions: </strong>This study provides evidence of substantial excess mortality from CVD, and notable reductions in respiratory disease and pneumonia in both years across most countries investigated. Our study also highlights the beneficial impact of stringent control measures in mitigating excess mortality from most causes in 2021.</p>\",\"PeriodicalId\":15796,\"journal\":{\"name\":\"Journal of Epidemiology and Global Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176135/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Epidemiology and Global Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s44197-024-00242-4\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Epidemiology and Global Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s44197-024-00242-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/22 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Cause-Specific Excess Mortality During the COVID-19 Pandemic (2020-2021) in 12 Countries of the C-MOR Consortium.
Background: This study investigated cause-specific mortality rates in 12 countries during the COVID-19 pandemic in 2020 and 2021.
Methods: We collected weekly cause-specific mortality data from respiratory disease, pneumonia, cardiovascular disease (CVD) and cancer from national vital statistic databases. We calculated excess mortality for respiratory disease (excluding COVID-19 codes), pneumonia, and CVD in 2020 and 2021 by comparing observed weekly against expected mortality based on historical data (2015-2019), accounting for seasonal trends. We used multilevel regression models to investigate the association between country-level pandemic-related variables and cause-specific mortality.
Results: Significant reductions in cumulative mortality from respiratory disease and pneumonia were observed in 2020 and/or 2021, except for Georgia, Northern Ireland, Kazakhstan, and Ukraine, which exhibited excess mortality for one or both causes. Australia, Austria, Cyprus, Georgia, and Northern Ireland experienced excess cumulative CVD mortality in 2020 and/or 2021. Australia, Austria, Brazil, Cyprus, Georgia, Northern Ireland, Scotland and Slovenia, experienced increased crude cumulative cancer mortality during 2020 and/or 2021 compared to previous years. Among pandemic-related variables, reported COVID-19 incidence was negatively associated with increased cancer mortality, excess respiratory, (2020) and pneumonia (2021) mortality, and positively associated with respiratory and CVD mortality (2021). Stringency of control measures were negatively associated with excess respiratory disease, CVD, and increased cancer mortality (2021).
Conclusions: This study provides evidence of substantial excess mortality from CVD, and notable reductions in respiratory disease and pneumonia in both years across most countries investigated. Our study also highlights the beneficial impact of stringent control measures in mitigating excess mortality from most causes in 2021.
期刊介绍：
The Journal of Epidemiology and Global Health is an esteemed international publication, offering a platform for peer-reviewed articles that drive advancements in global epidemiology and international health. Our mission is to shape global health policy by showcasing cutting-edge scholarship and innovative strategies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
