探索非编码 RNA 在心肌细胞命运中的作用

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Diego Franco, Cristina Sánchez-Fernández, Carlos García-Padilla, Estefania Lozano-Velasco
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引用次数: 0

摘要

心肌细胞命运的指定发生在心脏发育的早期阶段,因为心肌前中胚层被配置成两组对称的双侧前体细胞。周围组织的分子线索指定并随后决定了早期心肌细胞,这些细胞最终在出生后早期心脏发育完成时成熟。在过去的十年中,我们对心脏发育的转录调控以及心肌细胞命运的了解有了很大的提高。最近,我们发现了非编码 RNA 对基因调控的一个新的层次,这使得非编码 RNA 在心脏发育的表观遗传、转录和转录后调控中的作用更加突出。在这篇综述中,我们回顾了目前关于非编码 RNA 在心肌细胞命运过程中的功能作用的最新知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the role non-coding RNAs during myocardial cell fate.

Myocardial cell fate specification takes place during the early stages of heart development as the precardiac mesoderm is configured into two symmetrical sets of bilateral precursor cells. Molecular cues of the surrounding tissues specify and subsequently determine the early cardiomyocytes, that finally matured as the heart is completed at early postnatal stages. Over the last decade, we have greatly enhanced our understanding of the transcriptional regulation of cardiac development and thus of myocardial cell fate. The recent discovery of a novel layer of gene regulation by non-coding RNAs has flourished their implication in epigenetic, transcriptional and post-transcriptional regulation of cardiac development. In this review, we revised the current state-of-the-art knowledge on the functional role of non-coding RNAs during myocardial cell fate.

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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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