次生代谢物生物合成中依赖 F420 的转化

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2024-05-21 DOI:10.1016/j.cbpa.2024.102468

Ghader Bashiri

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引用次数: 0

摘要

辅因子 F420 在历史上一直被称为 "产甲烷氧化还原辅因子"。现在人们认识到，F420 在古细菌和细菌的初级和次级代谢中发挥着重要作用。最近的发现突显了 F420 作为氧化还原辅助因子在各种天然产物生物合成中的作用，包括核糖体合成和翻译后修饰的肽，以及一类新的烟酰胺腺嘌呤二核苷酸类次级代谢产物。随着大量（元）基因组数据的出现，鉴定未表征的依赖 F420 的酶为发现新型次级代谢产物提供了可能，为临床和生物技术应用带来了宝贵的前景。

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F420-dependent transformations in biosynthesis of secondary metabolites

Cofactor F₄₂₀ has been historically known as the “methanogenic redox cofactor”. It is now recognised that F₄₂₀ has essential roles in the primary and secondary metabolism of archaea and bacteria. Recent discoveries highlight the role of F₄₂₀ as a redox cofactor in the biosynthesis of various natural products, including ribosomally synthesised and post-translationally modified peptides, and a new class of nicotinamide adenine dinucleotide-based secondary metabolites. With the vast availability of (meta)genomic data, the identification of uncharacterised F₄₂₀-dependent enzymes offers the potential for discovering novel secondary metabolites, presenting valuable prospects for clinical and biotechnological applications.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.