次生代谢物生物合成中依赖 F420 的转化

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-05-21 DOI:10.1016/j.cbpa.2024.102468

Ghader Bashiri

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引用次数: 0

摘要

辅因子 F420 在历史上一直被称为 "产甲烷氧化还原辅因子"。现在人们认识到，F420 在古细菌和细菌的初级和次级代谢中发挥着重要作用。最近的发现突显了 F420 作为氧化还原辅助因子在各种天然产物生物合成中的作用，包括核糖体合成和翻译后修饰的肽，以及一类新的烟酰胺腺嘌呤二核苷酸类次级代谢产物。随着大量（元）基因组数据的出现，鉴定未表征的依赖 F420 的酶为发现新型次级代谢产物提供了可能，为临床和生物技术应用带来了宝贵的前景。

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F420-dependent transformations in biosynthesis of secondary metabolites

Cofactor F₄₂₀ has been historically known as the “methanogenic redox cofactor”. It is now recognised that F₄₂₀ has essential roles in the primary and secondary metabolism of archaea and bacteria. Recent discoveries highlight the role of F₄₂₀ as a redox cofactor in the biosynthesis of various natural products, including ribosomally synthesised and post-translationally modified peptides, and a new class of nicotinamide adenine dinucleotide-based secondary metabolites. With the vast availability of (meta)genomic data, the identification of uncharacterised F₄₂₀-dependent enzymes offers the potential for discovering novel secondary metabolites, presenting valuable prospects for clinical and biotechnological applications.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.