冠状动脉搭桥植入物的比较分析:实验与流体-结构相互作用分析

IF 5.3 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Shirin Changizi , Nima Afrasiabian , Aisa Rassoli , Nasser Fatouraee , Seyed Hossein Ahmadi Tafti
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引用次数: 0

摘要

搭桥手术是治疗冠状动脉疾病的常用方法,包括使用移植物搭桥闭塞的动脉。然而,由于移植物和原生动脉在机械性能上的差异,移植物闭塞仍是一个令人担忧的问题。本研究旨在比较冠状动脉搭桥手术中常用的三种移植物的机械性能:人体大隐静脉、乳腺动脉和桡动脉。对从这些血管中获取的样本进行了应力松弛试验,并对其机械特性进行了表征。使用准线性粘弹性(QLV)模型拟合每个样本的应力-应变曲线,并使用 MATLAB 软件提取模型常数。此外,还利用提取的血管粘弹性机械性能进行了流体-结构模拟。分析结果显示,在所研究的移植物中,大隐静脉的弹性系数(0.5247)和非线性系数(0.8135)最高。与其他移植物相比,乳腺动脉的粘弹性几乎高出七倍。此外,剪切应力分布检查显示,桡动脉和乳腺动脉样本的剪切应力区域低于隐静脉样本。值得注意的是,宿主动脉的下壁显示出最大的振荡剪切指数(OSI),与其他两种样本相比,桡动脉样本在该区域显示出最大的振荡。本研究中展示的力学表征结果有望应用于心脏病的病理和临床研究,帮助开发适当的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comparative analysis of coronary bypass implants: Experimental and fluid-structure interaction analysis

Bypass surgery is a commonly employed method for treating coronary artery diseases, involving the use of grafts to bypass occluded arteries. However, graft occlusion remains a concern due to mechanical disparities between the grafts and native arteries. This study aims to compare the mechanical properties of three frequently used grafts in coronary bypass surgeries: human saphenous veins, mammary arteries, and radial arteries. Stress-relaxation tests were conducted on samples obtained from these vessels, and their mechanical properties were characterized. The stress–strain curves of each sample were fitted using the quasi-linear viscoelastic (QLV) model, with MATLAB software used to extract the model's constants. Additionally, fluid–structure simulations were performed employing the extracted viscoelastic mechanical properties of the vessels. The analysis revealed that the saphenous vein exhibited the highest elastic coefficient (0.5247) and non-linearity coefficient (0.8135) among the studied grafts. The mammary artery demonstrated nearly seven times greater viscoelasticity compared to the other graft options. Furthermore, the examination of shear stress distribution indicated lower shear stress regions in the radial and mammary artery specimens compared to the saphenous specimens. Notably, the lower wall of the host artery exhibited the greatest oscillatory shear index (OSI), with the radial specimen displaying the highest oscillation in this region compared to the other two specimens. The mechanical characterization results presented in this study hold potential applications in pathogenic and clinical investigations of heart diseases, aiding in the development of appropriate treatment approaches.

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来源期刊
CiteScore
16.50
自引率
6.20%
发文量
77
审稿时长
38 days
期刊介绍: Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.
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