先天性心脏病管理的变革:胎儿心脏干预的进展。

IF 2.7 2区 医学 Q2 GENETICS & HEREDITY
Prenatal Diagnosis Pub Date : 2024-06-01 Epub Date: 2024-05-20 DOI:10.1002/pd.6592
Stephanie Guseh, Wayne Tworetzky
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引用次数: 0

摘要

本综述探讨了胎儿心脏介入(FCI)治疗先天性心脏病(CHD)的变革性进展,尤其关注主动脉瓣狭窄伴左心发育不全综合征(hypoplastic left heart syndrome)、肺动脉闭锁伴完整室间隔(pulmonary atresia with an intact ventricular septum)和HLHS伴完整房间隔(HLHS-IAS)。我们概述了所采用的特定 FCI 技术、选择合适的胎儿和母体候选者的细化标准,以及与这些手术相关的充满希望但又各不相同的结果。考虑到胎儿的病理生理学以及早期干预的益处和风险,我们对手术策略和临床决策进行了研究。我们强调了多学科团队在提高技术成功率和处理即时手术并发症方面的作用,这使得手术结果得到了显著改善。此外,综述还讨论了 FCI 的长期成果、挑战和未来研究方向,强调了持续创新和跨专业合作以推进心脏病管理的必要性。新技术和研究成果的整合有望进一步提高 FCI 的成功率和患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transforming congenital heart disease management: Advances in fetal cardiac interventions.

This review addresses the transformative advancements in fetal cardiac interventions (FCI) for congenital heart diseases (CHD), with a particular focus on aortic stenosis with evolving hypoplastic left heart syndrome, pulmonary atresia with an intact ventricular septum, and HLHS with an intact atrial septum (HLHS-IAS). We outline the specific FCI techniques employed, the refined criteria for selecting appropriate fetal and maternal candidates, and the promising yet varied outcomes associated with these procedures. Procedural strategies and clinical decision-making are examined as we take into account the fetal pathophysiology and the benefits and risks of early intervention. We highlight the role of multidisciplinary teams in improving technical success and managing immediate procedural complications, which have led to significant improvements in procedural outcomes. Additionally, the review discusses the long-term outcomes, challenges, and future research directions in FCI, emphasizing the necessity for continuous innovation and collaboration across specialties to advance the management of CHD. The integration of new technologies and research findings holds the promise of further enhancing FCI success rates and patient outcomes.

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来源期刊
Prenatal Diagnosis
Prenatal Diagnosis 医学-妇产科学
CiteScore
5.80
自引率
13.30%
发文量
204
审稿时长
2 months
期刊介绍: Prenatal Diagnosis welcomes submissions in all aspects of prenatal diagnosis with a particular focus on areas in which molecular biology and genetics interface with prenatal care and therapy, encompassing: all aspects of fetal imaging, including sonography and magnetic resonance imaging; prenatal cytogenetics, including molecular studies and array CGH; prenatal screening studies; fetal cells and cell-free nucleic acids in maternal blood and other fluids; preimplantation genetic diagnosis (PGD); prenatal diagnosis of single gene disorders, including metabolic disorders; fetal therapy; fetal and placental development and pathology; development and evaluation of laboratory services for prenatal diagnosis; psychosocial, legal, ethical and economic aspects of prenatal diagnosis; prenatal genetic counseling
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