石榴(Punica granatum L.)植物化学物质针对代谢综合征的成分。

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Lucas Fornari Laurindo , Victória Dogani Rodrigues , Giulia Minniti , Antonelly Cassio Alves de Carvalho , Tereza Laís Menegucci Zutin , Lindsay K. DeLiberto , Anupam Bishayee , Sandra Maria Barbalho
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引用次数: 0

摘要

石榴(Punica granatum L.)是一种多用途膳食和药用植物,因其能够促进各种健康益处而闻名。代谢综合征(MetS)是一种复杂的代谢紊乱,在全球范围内对健康和社会经济造成挑战。其特征可能是胰岛素抵抗、腹部肥胖、高血压和血脂异常。本研究旨在以临床前研究为基础,采用机理研究的方法对石榴对代谢综合征参数的影响进行综述。石榴的果皮、果汁、根、树皮、种子、花和叶中含有多种生物活性化合物,主要与抗炎和抗氧化活性以及心脏保护、抗糖尿病和抗肥胖作用有关。使用果汁提取物可以有效抑制血管紧张素转换酶的活性,从而调节血压。水果中的主要生物活性化合物是酚类化合物(可水解单宁酸和类黄酮)和脂肪酸。此外,还含有生物碱、punicalagin、鞣花丹宁、鞣花酸、花青素、单宁、类黄酮、木犀草素和布匿酸。石榴的抗高血糖、抗高血脂和减肥功效可能与抗炎和抗氧化作用有关。在考虑临床应用时,我们发现石榴提取物通常具有良好的耐受性,这进一步支持了其作为一种治疗方式的功效。我们建议,石榴果实、提取物或加工产品可用于对抗 MetS 相关风险因素。本综述是探索该领域进一步研究潜在途径的重要一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pomegranate (Punica granatum L.) phytochemicals target the components of metabolic syndrome

Pomegranate (Punica granatum L.) is a multipurpose dietary and medicinal plant known for its ability to promote various health benefits. Metabolic syndrome (MetS) is a complex metabolic disorder driving health and socioeconomic challenges worldwide. It may be characterized by insulin resistance, abdominal obesity, hypertension, and dyslipidemia. This study aims to conduct a review of pomegranate's effects on MetS parameters using a mechanistic approach relying on pre-clinical studies. The peel, juice, roots, bark, seeds, flowers, and leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, and antiobesity effects. The use of the juice extract can work as a potent inhibitor of angiotensin-converting enzyme activities, consequently regulating blood pressure. The major bioactive compounds found within the fruit are phenolic compounds (hydrolysable tannins and flavonoids) and fatty acids. Alkaloids, punicalagin, ellagitannins, ellagic acid, anthocyanins, tannins, flavonoids, luteolin, and punicic acid are also present. The antihyperglycemia, antihyperlipidemia, and weight loss promoting effects are likely related to the anti-inflammatory and antioxidant effects. When considering clinical application, pomegranate extracts are found to be frequently well-tolerated, further supporting its efficacy as a treatment modality. We suggest that pomegranate fruit, extract, or processed products can be used to counteract MetS-related risk factors. This review represents an important step towards exploring potential avenues for further research in this area.

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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
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