利用大型医院报销数据库评估日本胰腺癌患者的实际治疗时间:SUISEI 研究》。

IF 1.7 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Pancreas Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI:10.1097/MPA.0000000000002321
Hideki Ueno, Kyoko Shimizu, Ayako Fukui, Masahiro Nii, Ryo Koto, Michiaki Unno
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引用次数: 0

摘要

摘要阐明日本胰腺癌的治疗现状,重点关注治疗持续时间和死亡时间:我们回顾性分析了2009年4月至2018年10月期间确诊为胰腺癌患者的日本医院报销数据,以调查治疗模式、一线化疗持续时间和死亡时间:在81185名符合条件的患者中,54.2%为男性,平均年龄为71.7岁,23.3%(n = 18884)的患者接受了化疗作为主要治疗手段。6.7%的患者接受了奥沙利铂、伊立替康、氟尿嘧啶和白求恩(FOLFIRINOX,推荐一线方案)治疗,中位治疗时间为14.1周;30.2%的患者接受了吉西他滨+纳布-紫杉醇(GEM + nab-PTX)治疗,中位治疗时间为16.9周。接受 FOLFIRINOX 或 GEM + nab-PTX 治疗的患者的死亡时间相似(分别为 15.4 个月和 14.8 个月)。两种方案的一线化疗持续时间都有逐年延长的趋势。所有一线化疗方案的死亡时间也逐年增加:这项研究揭示了胰腺癌在日本的实际治疗情况。结论:这项研究揭示了日本现实世界中胰腺癌治疗的实际情况。治疗时间和死亡时间往往随着时间的推移而延长,FOLFIRINOX 和 GEM + nab-PTX 在数字上没有差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the Treatment Duration of Japanese Patients With Pancreatic Cancer in a Real-World Setting Using a Large Hospital Claims Database: The SUISEI Study.

Objectives: To clarify the treatment reality of pancreatic cancer in Japan, focusing on treatment duration and time to death.

Materials and methods: We retrospectively analyzed Japanese hospital claims data for patients diagnosed with pancreatic cancer between April 2009 and October 2018 to investigate treatment patterns, duration of first-line chemotherapy, and time to death.

Results: Of 81,185 eligible patients, 54.2% were male, the mean age was 71.7 years, and 23.3% (n = 18,884) received chemotherapy as primary treatment. The median treatment duration was 14.1 weeks for the 6.7% of patients who received oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX; recommended first-line regimen) and 16.9 weeks for the 30.2% of patients who received gemcitabine plus nab-paclitaxel (GEM + nab-PTX). Time to death for patients who received FOLFIRINOX or GEM + nab-PTX was similar (15.4 and 14.8 months, respectively). The duration of first-line chemotherapy regimens tended to increase annually for both regimens. The time to death for all first-line chemotherapy regimens also increased annually.

Conclusions: This study revealed the treatment reality of pancreatic cancer in the real-world Japanese setting. Treatment duration and time to death tended to increase over time and did not differ numerically between FOLFIRINOX and GEM + nab-PTX.

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来源期刊
Pancreas
Pancreas 医学-胃肠肝病学
CiteScore
4.70
自引率
3.40%
发文量
289
审稿时长
1 months
期刊介绍: Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.
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