HES4 控制氧化还原平衡，支持嘧啶合成和肿瘤生长

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-05-20 DOI:10.1038/s41594-024-01310-w

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引用次数: 0

摘要

NAD(H)氧化还原平衡在细胞代谢中起着基础性作用。我们利用基因组规模的 RNA 干扰（RNAi）方法，结合对 NAD（H）氧化还原状态敏感的高性能传感器 SoNar，筛选出了 NAD（H）的潜在调节因子。我们的分析确定了 HES4 是 NADH/NAD+ 比率的负调控因子，它影响嘧啶的生物合成并产生强烈的致癌作用。

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HES4 controls redox balance and supports pyrimidine synthesis and tumor growth

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HES4 controls redox balance and supports pyrimidine synthesis and tumor growth

NAD(H) redox homeostasis has a fundamental role in cellular metabolism. We screened for potential modulators of NAD(H) using a genome-scale RNA interference (RNAi) approach combined with SoNar, a high-performance sensor that is sensitive to the redox state of NAD(H). Our analysis identified HES4 as a negative regulator of the NADH/NAD+ ratio that influences pyrimidine biosynthesis and exerts a potent oncogenic effect.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.