Rasha M. Abddelgader , Sarvenaz Karamooz , Hosoon Choi , Munok Hwang , Chetan Jinadatha , Dhammika H. Navarathna
{"title":"Trueperella bernardiae引起的皮肤脓肿：病例报告和文献综述","authors":"Rasha M. Abddelgader , Sarvenaz Karamooz , Hosoon Choi , Munok Hwang , Chetan Jinadatha , Dhammika H. Navarathna","doi":"10.1016/j.idcr.2024.e01985","DOIUrl":null,"url":null,"abstract":"<div><p>We investigated a skin abscess caused by <em>Trueperella bernardiae</em> in a patient with comorbidities. Initial empirical therapy with Clindamycin did not yield a response, and follow-up culture revealed the presence of <em>T. bernardiae</em> through MALDI-TOF and NGS. Since no CLSI or FDA breakpoints have been published for this strain, resistant gene screening of the genetic sequence showed the presence of the erm(X) gene (with 95 % identity). This gene confers resistance to erythromycin, clindamycin, lincomycin, pristinamycin, quinupristin, and virginiamycin. Subsequent therapy with oral amoxicillin/clavulanate led to complete healing.</p></div>","PeriodicalId":47045,"journal":{"name":"IDCases","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214250924000611/pdfft?md5=ef2e8b2146d0e0ecb619af5b3ec71846&pid=1-s2.0-S2214250924000611-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Skin abscess caused by Trueperella bernardiae: Case report and literature review\",\"authors\":\"Rasha M. Abddelgader , Sarvenaz Karamooz , Hosoon Choi , Munok Hwang , Chetan Jinadatha , Dhammika H. Navarathna\",\"doi\":\"10.1016/j.idcr.2024.e01985\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We investigated a skin abscess caused by <em>Trueperella bernardiae</em> in a patient with comorbidities. Initial empirical therapy with Clindamycin did not yield a response, and follow-up culture revealed the presence of <em>T. bernardiae</em> through MALDI-TOF and NGS. Since no CLSI or FDA breakpoints have been published for this strain, resistant gene screening of the genetic sequence showed the presence of the erm(X) gene (with 95 % identity). This gene confers resistance to erythromycin, clindamycin, lincomycin, pristinamycin, quinupristin, and virginiamycin. Subsequent therapy with oral amoxicillin/clavulanate led to complete healing.</p></div>\",\"PeriodicalId\":47045,\"journal\":{\"name\":\"IDCases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2214250924000611/pdfft?md5=ef2e8b2146d0e0ecb619af5b3ec71846&pid=1-s2.0-S2214250924000611-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IDCases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214250924000611\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IDCases","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214250924000611","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Skin abscess caused by Trueperella bernardiae: Case report and literature review
We investigated a skin abscess caused by Trueperella bernardiae in a patient with comorbidities. Initial empirical therapy with Clindamycin did not yield a response, and follow-up culture revealed the presence of T. bernardiae through MALDI-TOF and NGS. Since no CLSI or FDA breakpoints have been published for this strain, resistant gene screening of the genetic sequence showed the presence of the erm(X) gene (with 95 % identity). This gene confers resistance to erythromycin, clindamycin, lincomycin, pristinamycin, quinupristin, and virginiamycin. Subsequent therapy with oral amoxicillin/clavulanate led to complete healing.
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