大鼠服用异维A酸的治疗剂量可能会影响牙齿矫正运动

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM
Mayra Fernanda Ferreira , Alberto Carlos Botazzo Delbem , Edilson Ervolino , Luy de Abreu Costa , Cristina Antoniali Silva , José Ricardo Prando dos Santos , Marcos Rogério de Mendonça
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引用次数: 0

摘要

异维A酸又称13-顺式维A酸,是维A酸的一种异构体,是维生素A的氧化形式。异维A酸主要用于青少年和年轻人,巧合的是,这个年龄组的人也在接受正畸治疗。材料和方法 使用 55 只动物,将其随机分为 11 组,每组 5 只。第一组:对照组;第二组OTM治疗7天;第3组:OTM治疗14天;第4组:异维A酸治疗14天,剂量为7.5毫克/千克/天;第5组:异维A酸治疗14天,剂量为1.0毫克/千克/天;第6组:异维A酸治疗21天,剂量为7.5毫克/千克/天;第7组:使用异维A酸治疗21天,剂量为1.0毫克/千克/天;第8组:使用异维A酸治疗14天,剂量为7.5毫克/千克/天,并接受OTM治疗7天;第9组:使用异维A酸治疗14天,剂量为1.0毫克/千克/天,并接受OTM治疗7天;第10组:使用异维A酸治疗14天,剂量为1.0毫克/千克/天,并接受OTM治疗7天:第 10 组:使用异维A酸治疗 21 天,剂量为 7.5 毫克/公斤/天,并接受 OTM 治疗 14 天;第 11 组:使用异维A酸治疗 21 天,剂量为 1.0 毫克/公斤/天,并接受 OTM 治疗 14 天。结果 各组之间的小梁体积(BV/TV)、小梁厚度(Tb.Th)、小梁数目(Tb.N)和小梁分离度(Tb.Sp)等显微形态学参数存在显著差异。在 21 天和 14 天的治疗期间,接受正畸力和 7.5 毫克/千克/天的异维A酸治疗的组的牙齿移位率较低。结论 当异维A酸的剂量为7.5毫克/千克/天时,异维A酸可减少OTM期间的牙齿移位,而且异维A酸确实改变了接受治疗动物的显微解剖参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Therapeutic dosage of isotretinoin in rats may influence orthodontic tooth movement

Therapeutic dosage of isotretinoin in rats may influence orthodontic tooth movement

Objective Isotretinoin, also known as 13-cis-retinoic acid, is an isomer of tretinoin, the oxidized form of Vitamin A. Orthodontic tooth movement (OTM) is the result of a cascade of inflammatory responses stimulated by a physical element that is the force generated by orthodontic appliances. Isotretinoin is mainly used among adolescents and young adults, and coincidentally it is this age group that also undergoes orthodontic treatment. Materials and Methods Fifty-five animals were used, and they were randomly divided into 11 groups, containing 5 animals in each group. Group 1: Control; Group 2: OTM for 7 days; Group 3: OTM for 14 days; Group 4: Treated with isotretinoin for 14 days with a dosage of 7.5 mg/kg/day; Group 5: Treated with isotretinoin for 14 days with a dosage of 1.0 mg/kg/day; Group 6: Treated with isotretinoin for 21 days with a dosage of 7.5 mg/kg/day; Group 7: Treated with isotretinoin for 21 days with a dosage of 1.0 mg/kg/day; Group 8: Treated with isotretinoin for 14 days with a dosage of 7.5 mg/kg/day and undergoing OTM for 7 days; Group 9: Treated with isotretinoin for 14 days with a dosage of 1.0 mg/kg/day and undergoing OTM for 7 days; Group 10: Treated with isotretinoin for 21 days with a dosage of 7.5 mg/kg/day and undergoing OTM for 14 days; Group 11: Treated with isotretinoin for 21 days with a dosage of 1.0 mg/kg/day and undergoing OTM for 14 days. In Groups 8, 9, 10 and 11, the animals were treated with isotretinoin for 7 days before OTM and maintained during the movement period in the respective groups.

Results There was a significant difference in microtomographic parameters, including Trabecular Volume (BV/TV), Trabecular Thickness (Tb.Th), Number of Trabeculae (Tb.N), and Trabecular Separation (Tb.Sp), between the groups. The group that received orthodontic force in conjunction with isotretinoin treatment at a dosage of 7.5 mg/kg/day exhibited lower tooth displacement over a period of 21 days and 14 days. Conclusion Isotretinoin caused a reduction in tooth displacement during OTM when administered at a dose of 7.5 mg/kg/day and isotretinoin did change the microtomographic parameters of treated animals.

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来源期刊
Bone Reports
Bone Reports Medicine-Orthopedics and Sports Medicine
CiteScore
4.30
自引率
4.00%
发文量
444
审稿时长
57 days
期刊介绍: Bone Reports is an interdisciplinary forum for the rapid publication of Original Research Articles and Case Reports across basic, translational and clinical aspects of bone and mineral metabolism. The journal publishes papers that are scientifically sound, with the peer review process focused principally on verifying sound methodologies, and correct data analysis and interpretation. We welcome studies either replicating or failing to replicate a previous study, and null findings. We fulfil a critical and current need to enhance research by publishing reproducibility studies and null findings.
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