联合施用白藜芦醇可缓解黑腹果蝇铅诱导的毒性。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-05-18 DOI:10.1016/j.etap.2024.104470

R. Abdulazeez , S.M. Highab , U.F. Onyawole , M.T. Jeje , H. Musa , D.M. Shehu , I.S. Ndams

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引用次数: 0

摘要

铅毒性是一个与多种健康问题相关的重大环境问题。本研究探讨了白藜芦醇对黑腹果蝇铅毒性的潜在缓解作用。将成年果蝇（3 天龄）口服铅（60 毫克/升）、琥珀酰亚胺（10 毫克）和不同浓度的白藜芦醇（50、100 和 150 毫克）。调查包括对选定生物参数、生化指标、氧化应激指标和抗氧化酶的评估。白藜芦醇对黑腹蝇蛆的产卵率、孵化率、子代产量、运动活性和寿命都有剂量依赖性的提高，显著提高到150毫克日粮的水平。与白藜芦醇联合处理后，铅暴露果蝇的大多数生化指标都有明显改善（p < 0.05）。然而，氧化应激仍然不受白藜芦醇的影响。研究结果表明，白藜芦醇能有效防止黑色果蝇的铅中毒，并有可能成为控制人类铅中毒的治疗剂。

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Co-administration of resveratrol rescued lead-induced toxicity in Drosophila melanogaster

Lead toxicity poses a significant environmental concern linked to diverse health issues. This study explores the potential mitigating effects of resveratrol on lead-induced toxicity in Drosophila melanogaster. Adult fruit flies, aged three days, were orally exposed to lead (60 mg/L), Succimer (10 mg), and varying concentrations of resveratrol (50, 100, and 150 mg). The investigation encompassed the assessment of selected biological parameters, biochemical markers, oxidative stress indicators, and antioxidant enzymes. Resveratrol exhibited a dose-dependent enhancement of egg-laying, eclosion rate, filial generation output, locomotor activity, and life span in D. melanogaster, significantly to 150 mg of diet. Most of the investigated biochemical parameters were significantly rescued in lead-exposed fruit flies when co-treated with resveratrol (p < 0.05). However, oxidative stress remained unaffected by resveratrol. The findings suggest that resveratrol effectively protects against lead toxicity in Drosophila melanogaster and may hold therapeutic potential as an agent for managing lead poisoning in humans.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.