Fernanda Santos Mendes, Marcelo Rizzatti Luizon, Ana Cristina Dos Santos Lopes, Daniela Alves Pereira, Fernanda Cristina Gontijo Evangelista, Lara Carvalho Godoi, Luci Maria Dusse, Patrícia Nessralla Alpoim
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引用次数: 0
摘要
目的研究DDAH2启动子多态性-1415G/A (rs2272592)、-1151A/C (rs805304)和-449G/C (rs805305)及其单倍型与正常血压孕妇的PE是否相关，以及是否会影响这些群体的ADMA水平：研究共纳入 208 名孕妇，分为早发 PE（57 人）或晚发 PE（49 人）以及血压正常孕妇（102 人）：结果：携带DDAH2 -449G/C多态性GC和GG基因型的早发型PE孕妇的ADMA水平升高（P=0.01）。在单病灶分析中，未发现 DDAH2 多态性与 PE 有关。然而，G-C-G单倍型与晚发PE的风险有关：结论：DDAH2 多态性可能会影响 PE 中的 ADMA 水平，DDAH2 单倍型可能会影响 PE 的发病风险。
Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes.
Objective: To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups.
Methods: A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102).
Results: Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE.
Conclusion: It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE.
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