Felona Gunawan, Brooke C. Matson, Anastasia Coppoli, Lihong Jiang, Yuyan Ding, Rachel Perry, Elizabeth Sanchez-Rangel, Renata Belfort DeAguiar, Kevin L. Behar, Douglas L. Rothman, Graeme F. Mason, Janice J. Hwang
{"title":"患有肥胖症的年轻成年人大脑葡萄糖转运功能存在缺陷。","authors":"Felona Gunawan, Brooke C. Matson, Anastasia Coppoli, Lihong Jiang, Yuyan Ding, Rachel Perry, Elizabeth Sanchez-Rangel, Renata Belfort DeAguiar, Kevin L. Behar, Douglas L. Rothman, Graeme F. Mason, Janice J. Hwang","doi":"10.1002/oby.24034","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Obesity is associated with alterations in eating behavior and neurocognitive function. In this study, we investigate the effect of obesity on brain energy utilization, including brain glucose transport and metabolism.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A total of 11 lean participants and 7 young healthy participants with obesity (mean age, 27 years) underwent magnetic resonance spectroscopy scanning coupled with a hyperglycemic clamp (target, ~180 mg/dL) using [1-<sup>13</sup>C] glucose to measure brain glucose uptake and metabolism, as well as peripheral markers of insulin resistance.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Individuals with obesity demonstrated an ~20% lower ratio of brain glucose uptake to cerebral glucose metabolic rate (T<sub>max</sub>/CMR<sub>glucose</sub>) than lean participants (2.12 ± 0.51 vs. 2.67 ± 0.51; <i>p</i> = 0.04). The cerebral tricarboxylic acid cycle flux (V<sub>TCA</sub>) was similar between the two groups (<i>p</i> = 0.64). There was a negative correlation between total nonesterified fatty acids and T<sub>max</sub>/CMR<sub>glucose</sub> (<i>r</i> = −0.477; <i>p</i> = 0.045).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>We conclude that CMR<sub>glucose</sub> is unlikely to differ between groups due to similar V<sub>TCA</sub>, and, therefore, the glucose transport T<sub>max</sub> is lower in individuals with obesity. These human findings suggest that obesity is associated with reduced cerebral glucose transport capacity even at a young age and in the absence of other cardiometabolic comorbidities, which may have implications for long-term brain function and health.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Deficits in brain glucose transport among younger adults with obesity\",\"authors\":\"Felona Gunawan, Brooke C. Matson, Anastasia Coppoli, Lihong Jiang, Yuyan Ding, Rachel Perry, Elizabeth Sanchez-Rangel, Renata Belfort DeAguiar, Kevin L. Behar, Douglas L. Rothman, Graeme F. Mason, Janice J. Hwang\",\"doi\":\"10.1002/oby.24034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Obesity is associated with alterations in eating behavior and neurocognitive function. In this study, we investigate the effect of obesity on brain energy utilization, including brain glucose transport and metabolism.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A total of 11 lean participants and 7 young healthy participants with obesity (mean age, 27 years) underwent magnetic resonance spectroscopy scanning coupled with a hyperglycemic clamp (target, ~180 mg/dL) using [1-<sup>13</sup>C] glucose to measure brain glucose uptake and metabolism, as well as peripheral markers of insulin resistance.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Individuals with obesity demonstrated an ~20% lower ratio of brain glucose uptake to cerebral glucose metabolic rate (T<sub>max</sub>/CMR<sub>glucose</sub>) than lean participants (2.12 ± 0.51 vs. 2.67 ± 0.51; <i>p</i> = 0.04). The cerebral tricarboxylic acid cycle flux (V<sub>TCA</sub>) was similar between the two groups (<i>p</i> = 0.64). There was a negative correlation between total nonesterified fatty acids and T<sub>max</sub>/CMR<sub>glucose</sub> (<i>r</i> = −0.477; <i>p</i> = 0.045).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>We conclude that CMR<sub>glucose</sub> is unlikely to differ between groups due to similar V<sub>TCA</sub>, and, therefore, the glucose transport T<sub>max</sub> is lower in individuals with obesity. These human findings suggest that obesity is associated with reduced cerebral glucose transport capacity even at a young age and in the absence of other cardiometabolic comorbidities, which may have implications for long-term brain function and health.</p>\\n </section>\\n </div>\",\"PeriodicalId\":215,\"journal\":{\"name\":\"Obesity\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/oby.24034\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24034","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Deficits in brain glucose transport among younger adults with obesity
Objective
Obesity is associated with alterations in eating behavior and neurocognitive function. In this study, we investigate the effect of obesity on brain energy utilization, including brain glucose transport and metabolism.
Methods
A total of 11 lean participants and 7 young healthy participants with obesity (mean age, 27 years) underwent magnetic resonance spectroscopy scanning coupled with a hyperglycemic clamp (target, ~180 mg/dL) using [1-13C] glucose to measure brain glucose uptake and metabolism, as well as peripheral markers of insulin resistance.
Results
Individuals with obesity demonstrated an ~20% lower ratio of brain glucose uptake to cerebral glucose metabolic rate (Tmax/CMRglucose) than lean participants (2.12 ± 0.51 vs. 2.67 ± 0.51; p = 0.04). The cerebral tricarboxylic acid cycle flux (VTCA) was similar between the two groups (p = 0.64). There was a negative correlation between total nonesterified fatty acids and Tmax/CMRglucose (r = −0.477; p = 0.045).
Conclusions
We conclude that CMRglucose is unlikely to differ between groups due to similar VTCA, and, therefore, the glucose transport Tmax is lower in individuals with obesity. These human findings suggest that obesity is associated with reduced cerebral glucose transport capacity even at a young age and in the absence of other cardiometabolic comorbidities, which may have implications for long-term brain function and health.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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