{"title":"埃塞俄比亚废物处理人员的乙型肝炎和丙型肝炎病毒血清阳性率:系统回顾和荟萃分析。","authors":"Alemu Gedefie, Fekadeselassie Belege Getaneh, Habtu Debash, Saleamlak Sebsibe, Yonas Erkihun, Ermiyas Alemayehu, Yeshi Metaferia, Yeshimebet Kassa, Agumas Shibabaw, Mihret Tilahun, Getachew Mesfin Bambo, Samuel Sahile Kebede, Mekuanent Alemu, Wondmagegn Demsiss","doi":"10.1177/20503121241247685","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Hepatitis B virus and hepatitis C virus are the leading causes of global liver-related morbidity and mortality. Waste handlers are one of the high-risk groups for hepatitis B virus and hepatitis C virus acquisition. Thus, the aim of this study was to assess the pooled prevalence of hepatitis B virus and hepatitis C virus among waste handlers in Ethiopia.</p><p><strong>Methods: </strong>Articles were extensively searched in bibliographic databases and gray literature using entry terms or phrases. Studies meeting eligibility criteria were extracted in MS Excel and exported to STATA version 14 software for statistical analysis. A random-effects model was used to compute the pooled magnitude of hepatitis B virus and hepatitis C virus. Heterogeneity was quantified by using the <i>I</i><sup>2</sup> value. Publication bias was assessed using a funnel plot and Egger's test. Sensitivity analysis was performed to assess the impact of a single study on pooled effect size.</p><p><strong>Result: </strong>Of the 116 studies identified, 8 studies were selected for meta-analysis. All studies reported hepatitis B virus, while 5 studies reported hepatitis C virus infection among waste handlers. The overall pooled prevalence of hepatitis B virus and hepatitis C virus infection among waste handlers in Ethiopia was 5.07% (2.0-8.15) and 1.46% (0.52-2.4), respectively. Moreover, the pooled prevalence of lifetime hepatitis B virus exposure among Ethiopian waste handlers was 33.98% (95% CI: 21.24-46.72). Hepatitis B virus and hepatitis C virus infection were not statistically associated with the type of waste handlers, that is, there was no difference between medical and nonmedical waste handlers.</p><p><strong>Prospero registration: </strong>CRD42023398686.</p><p><strong>Conclusion: </strong>The pooled prevalence of hepatitis B virus and hepatitis C virus infection among waste handlers in Ethiopia was intermediate and moderate, respectively. This showed that there is a strong need to scale up preventive efforts and strategic policy directions to limit the spread of these viruses. Moreover, we also conclude that handling healthcare and domestic waste is associated with a similar risk of hepatitis B virus and hepatitis C virus infection.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102692/pdf/","citationCount":"0","resultStr":"{\"title\":\"Seroprevalence of hepatitis B and C viruses among waste handlers in Ethiopia: A systematic review and meta-analysis.\",\"authors\":\"Alemu Gedefie, Fekadeselassie Belege Getaneh, Habtu Debash, Saleamlak Sebsibe, Yonas Erkihun, Ermiyas Alemayehu, Yeshi Metaferia, Yeshimebet Kassa, Agumas Shibabaw, Mihret Tilahun, Getachew Mesfin Bambo, Samuel Sahile Kebede, Mekuanent Alemu, Wondmagegn Demsiss\",\"doi\":\"10.1177/20503121241247685\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Hepatitis B virus and hepatitis C virus are the leading causes of global liver-related morbidity and mortality. Waste handlers are one of the high-risk groups for hepatitis B virus and hepatitis C virus acquisition. Thus, the aim of this study was to assess the pooled prevalence of hepatitis B virus and hepatitis C virus among waste handlers in Ethiopia.</p><p><strong>Methods: </strong>Articles were extensively searched in bibliographic databases and gray literature using entry terms or phrases. Studies meeting eligibility criteria were extracted in MS Excel and exported to STATA version 14 software for statistical analysis. A random-effects model was used to compute the pooled magnitude of hepatitis B virus and hepatitis C virus. Heterogeneity was quantified by using the <i>I</i><sup>2</sup> value. Publication bias was assessed using a funnel plot and Egger's test. Sensitivity analysis was performed to assess the impact of a single study on pooled effect size.</p><p><strong>Result: </strong>Of the 116 studies identified, 8 studies were selected for meta-analysis. All studies reported hepatitis B virus, while 5 studies reported hepatitis C virus infection among waste handlers. The overall pooled prevalence of hepatitis B virus and hepatitis C virus infection among waste handlers in Ethiopia was 5.07% (2.0-8.15) and 1.46% (0.52-2.4), respectively. Moreover, the pooled prevalence of lifetime hepatitis B virus exposure among Ethiopian waste handlers was 33.98% (95% CI: 21.24-46.72). Hepatitis B virus and hepatitis C virus infection were not statistically associated with the type of waste handlers, that is, there was no difference between medical and nonmedical waste handlers.</p><p><strong>Prospero registration: </strong>CRD42023398686.</p><p><strong>Conclusion: </strong>The pooled prevalence of hepatitis B virus and hepatitis C virus infection among waste handlers in Ethiopia was intermediate and moderate, respectively. This showed that there is a strong need to scale up preventive efforts and strategic policy directions to limit the spread of these viruses. Moreover, we also conclude that handling healthcare and domestic waste is associated with a similar risk of hepatitis B virus and hepatitis C virus infection.</p>\",\"PeriodicalId\":21398,\"journal\":{\"name\":\"SAGE Open Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-05-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102692/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SAGE Open Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/20503121241247685\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SAGE Open Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20503121241247685","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
目的:乙型肝炎病毒和丙型肝炎病毒是全球肝脏相关疾病发病率和死亡率的主要原因。废物处理人员是感染乙型肝炎病毒和丙型肝炎病毒的高危人群之一。因此,本研究旨在评估埃塞俄比亚废物处理人员中乙型肝炎病毒和丙型肝炎病毒的总体流行率:使用词条或短语在书目数据库和灰色文献中广泛检索文章。在 MS Excel 中提取符合资格标准的研究,并导出到 STATA 14 版软件中进行统计分析。采用随机效应模型计算乙型肝炎病毒和丙型肝炎病毒的总和。异质性通过 I2 值进行量化。使用漏斗图和 Egger 检验评估发表偏倚。进行了敏感性分析,以评估单项研究对汇总效应大小的影响:在确定的 116 项研究中,有 8 项研究被选中进行荟萃分析。所有研究都报告了乙型肝炎病毒,5 项研究报告了废物处理人员感染丙型肝炎病毒的情况。埃塞俄比亚废物处理人员中乙型肝炎病毒和丙型肝炎病毒感染的总合流行率分别为 5.07%(2.0-8.15)和 1.46%(0.52-2.4)。此外,埃塞俄比亚废物处理人员终生暴露于乙型肝炎病毒的总体流行率为 33.98%(95% CI:21.24-46.72)。乙型肝炎病毒和丙型肝炎病毒感染与废物处理者的类型没有统计学关联,即医疗废物处理者和非医疗废物处理者之间没有差异:CRD42023398686.Conclusion:埃塞俄比亚废物处理人员中乙型肝炎病毒和丙型肝炎病毒感染的总体流行率分别为中度和中度。这表明,亟需加强预防工作和战略政策指导,以限制这些病毒的传播。此外,我们还得出结论,处理医疗废物和生活垃圾与感染乙型肝炎病毒和丙型肝炎病毒的风险相似。
Seroprevalence of hepatitis B and C viruses among waste handlers in Ethiopia: A systematic review and meta-analysis.
Objective: Hepatitis B virus and hepatitis C virus are the leading causes of global liver-related morbidity and mortality. Waste handlers are one of the high-risk groups for hepatitis B virus and hepatitis C virus acquisition. Thus, the aim of this study was to assess the pooled prevalence of hepatitis B virus and hepatitis C virus among waste handlers in Ethiopia.
Methods: Articles were extensively searched in bibliographic databases and gray literature using entry terms or phrases. Studies meeting eligibility criteria were extracted in MS Excel and exported to STATA version 14 software for statistical analysis. A random-effects model was used to compute the pooled magnitude of hepatitis B virus and hepatitis C virus. Heterogeneity was quantified by using the I2 value. Publication bias was assessed using a funnel plot and Egger's test. Sensitivity analysis was performed to assess the impact of a single study on pooled effect size.
Result: Of the 116 studies identified, 8 studies were selected for meta-analysis. All studies reported hepatitis B virus, while 5 studies reported hepatitis C virus infection among waste handlers. The overall pooled prevalence of hepatitis B virus and hepatitis C virus infection among waste handlers in Ethiopia was 5.07% (2.0-8.15) and 1.46% (0.52-2.4), respectively. Moreover, the pooled prevalence of lifetime hepatitis B virus exposure among Ethiopian waste handlers was 33.98% (95% CI: 21.24-46.72). Hepatitis B virus and hepatitis C virus infection were not statistically associated with the type of waste handlers, that is, there was no difference between medical and nonmedical waste handlers.
Prospero registration: CRD42023398686.
Conclusion: The pooled prevalence of hepatitis B virus and hepatitis C virus infection among waste handlers in Ethiopia was intermediate and moderate, respectively. This showed that there is a strong need to scale up preventive efforts and strategic policy directions to limit the spread of these viruses. Moreover, we also conclude that handling healthcare and domestic waste is associated with a similar risk of hepatitis B virus and hepatitis C virus infection.