盐酸法莫替丁生物黏附性缓释混悬液的开发和体内外评估。

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Hongfei Liu, Jintong Dai, Jiangming He, Yang Xu, Caleb Kesse Firempong, Yingshu Feng, Haibing He
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引用次数: 0

摘要

通过筛选合适的辅料,设计合理的处方,提高患者的药物活性,达到预期的治疗效果,从而开发出一种新型法莫替丁树脂微胶囊,用于胃黏膜缓释。采用水浴法制备法莫替丁药物树脂,以卡波姆 934 作为包衣材料。采用乳化溶剂包衣法制备微胶囊,并使用适当的辅料制备法莫替丁缓释混悬液。研究了所开发微胶囊在大鼠胃肠道中的药代动力学。自制的盐酸法莫替丁缓释混悬液有效降低了大鼠的血药浓度并延长了作用时间。自制盐酸法莫替丁混悬液与市售盐酸法莫替丁的相对生物利用度为 146.44%,平均保留时间延长了约 5 小时,这表明新混悬液具有可接受的粘附性。研究结果表明,新开发的法莫替丁树脂微胶囊提高了药物的生物利用度,并具有显著的缓释特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and in vitro/in vivo evaluation of famotidine hydrochloride bioadhesive sustained release suspension.

To develop a new kind of famotidine-resin microcapsule for gastric adhesion sustained release by screening out suitable excipients and designing reasonable prescriptions to improve patient drug activities to achieve the expected therapeutic effect. The famotidine drug resin was prepared using the water bath method with carbomer 934 used as coating material. Microcapsules were prepared using the emulsified solvent coating method and appropriate excipients were used to prepare famotidine sustained release suspension. Pharmacokinetics of the developed microcapsules were studied in the gastrointestinal tract of rats. The self-made sustained-release suspension of famotidine hydrochloride effectively reduced the blood concentration and prolonged the action time. The relative bioavailability of the self-made suspension of the famotidine hydrochloride to the commercially available famotidine hydrochloride was 146.44%, with an average retention time of about 5h longer, which indicated that the new suspension had acceptable adhesion properties. The findings showed that the newly developed famotidine-resin microcapsule increased the bioavailability of the drug with a significant sustained-release property.

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来源期刊
CiteScore
1.40
自引率
12.50%
发文量
211
审稿时长
4.5 months
期刊介绍: Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.
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