分枝杆菌 T7SS（ESX）分泌系统功能研究进展。

Q3 Medicine

遗传 Pub Date : 2023-12-20 DOI:10.16288/j.yczz.23-188

Zhi-Yong Jiang, Jian-Ping Xie

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引用次数: 0

摘要

分枝杆菌感染可通过分泌细胞外效应蛋白影响宿主的免疫功能。ESX（或 VII 型）系统在分泌效应蛋白方面发挥着重要作用。ESX 系统是分枝杆菌和许多放线菌的蛋白质输出系统。然而，ESX 系统如何分泌及其作用机制仍不清楚。在这篇综述中，我们将介绍 ESX 系统的组成、功能、分类以及底物通过该系统转移到外周空间的过程，并讨论 ESX 系统在抗生素耐药性、持久性、宿主与噬菌体相互作用、新药靶点等方面的作用。我们希望能为结核病新药和疫苗抗原的发现提供启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress on the function of Mycobacterium T7SS (ESX) secretion system.

Mycobacterium infection can affect the host's immune function by secreting extracellular effector proteins. ESX (or type VII) system plays an important role in the secretion of effector proteins. ESX system is the protein export system in mycobacteria and many actinomycetes. However, how ESX system secretes and underlying mechanism of action remain unclear. In this review, we introduce the components, function, classification of ESX system and the process of substrates transfer to the peripheral space via this system, and discuss the roles of ESX system in antibiotics resistance, persistence, host-phage interaction, new drug targets. We hope to provide insights into the discovery of new drugs and vaccine antigens for tuberculosis.

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.