有机体制造和应用指南》：肾脏。

IF 2.5 4区医学 Q3 CELL & TISSUE ENGINEERING

International journal of stem cells Pub Date : 2024-05-30 Epub Date: 2024-05-20 DOI:10.15283/ijsc24040

Hyun Mi Kang, Dong Sung Kim, Yong Kyun Kim, Kunyoo Shin, Sun-Ju Ahn, Cho-Rok Jung

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引用次数: 0

摘要

类器官技术的最新进展推动了利用该技术替代动物实验的热潮。类器官技术应用广泛，特别是在药物或化学物质的毒性测试方面。然而，在毒性测试的实际应用中，需要最低限度的指导，以确保可靠性和相关性。本文旨在为实际使用源自人类多能干细胞的肾脏类器官作为体外毒性评估模型提供最低限度的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Guidelines for Manufacturing and Application of Organoids: Kidney.

Recent advancements in organoid technology have led to a vigorous movement towards utilizing it as a substitute for animal experiments. Organoid technology offers versatile applications, particularly in toxicity testing of pharmaceuticals or chemical substances. However, for the practical use in toxicity testing, minimal guidance is required to ensure reliability and relevance. This paper aims to provide minimal guidelines for practical uses of kidney organoids derived from human pluripotent stem cells as a toxicity evaluation model in vitro.

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来源期刊

International journal of stem cells Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.10

自引率

4.30%

发文量

期刊介绍： International Journal of Stem Cells (Int J Stem Cells), a peer-reviewed open access journal, principally aims to provide a forum for investigators in the field of stem cell biology to present their research findings and share their visions and opinions. Int J Stem Cells covers all aspects of stem cell biology including basic, clinical and translational research on genetics, biochemistry, and physiology of various types of stem cells including embryonic, adult and induced stem cells. Reports on epigenetics, genomics, proteomics, metabolomics of stem cells are welcome as well. Int J Stem Cells also publishes review articles, technical reports and treatise on ethical issues.