消除配体结构对钴(III)配合物还原率的影响

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-16 DOI:10.1134/S1070328423600699

I. A. Nikovskii, K. A. Spiridonov, A. A. Dan’shina, E. A. Khakina, Yu. V. Nelyubina

{"title":"消除配体结构对钴(III)配合物还原率的影响","authors":"I. A. Nikovskii, K. A. Spiridonov, A. A. Dan’shina, E. A. Khakina, Yu. V. Nelyubina","doi":"10.1134/S1070328423600699","DOIUrl":null,"url":null,"abstract":"<p>The reduction of the heteroleptic cobalt(III) complexes with bipyridine ligands of different structures of the model drug molecule is studied by in situ NMR spectroscopy. The nature of the ligand eliminated during reduction is shown to exert a substantial effect on the reduction rate, which indicates that an optimum amount of cobalt should be chosen for the redox-activated delivery of a certain drug.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influence of the Eliminated Ligand Structure on the Reduction Rate of the Cobalt(III) Complexes\",\"authors\":\"I. A. Nikovskii, K. A. Spiridonov, A. A. Dan’shina, E. A. Khakina, Yu. V. Nelyubina\",\"doi\":\"10.1134/S1070328423600699\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The reduction of the heteroleptic cobalt(III) complexes with bipyridine ligands of different structures of the model drug molecule is studied by in situ NMR spectroscopy. The nature of the ligand eliminated during reduction is shown to exert a substantial effect on the reduction rate, which indicates that an optimum amount of cobalt should be chosen for the redox-activated delivery of a certain drug.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070328423600699\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070328423600699","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

摘要利用原位核磁共振光谱研究了模型药物分子的不同结构的联吡啶配体还原异性钴（III）配合物的情况。还原过程中消除的配体的性质对还原速率有很大影响，这表明在氧化还原作用下输送某种药物时应选择最佳的钴量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Influence of the Eliminated Ligand Structure on the Reduction Rate of the Cobalt(III) Complexes

查看原文本刊更多论文

Influence of the Eliminated Ligand Structure on the Reduction Rate of the Cobalt(III) Complexes

The reduction of the heteroleptic cobalt(III) complexes with bipyridine ligands of different structures of the model drug molecule is studied by in situ NMR spectroscopy. The nature of the ligand eliminated during reduction is shown to exert a substantial effect on the reduction rate, which indicates that an optimum amount of cobalt should be chosen for the redox-activated delivery of a certain drug.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.