可溶性环氧化物水解酶：营养保健品对抗炎症和氧化应激的新靶点

IF 8.9 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Current Opinion in Food Science Pub Date : 2024-05-10 DOI:10.1016/j.cofs.2024.101174

Joy I Obeme-Nmom , Chibuike C Udenigwe

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引用次数: 0

摘要

可溶性环氧化物水解酶（sEH）催化环氧脂肪酸向二元醇的转化。环氧脂肪酸是一种信号分子，参与炎症、氧化还原状态调节、血压和痛觉等生理功能。下调各种细胞中的 sEH 活性已被用于治疗和控制各种心血管和神经退行性疾病。因此，抑制 sEH 是对抗炎症、氧化应激及其相关疾病的一个新兴靶点。本文讨论了从食物中提取的提取物和化合物（包括多酚、蛋白质水解物和肽类、原生物碱、三萜类和脂肪酸）抑制 sEH 的最新进展和未来展望。

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Soluble epoxide hydrolase: an emerging target for nutraceuticals against inflammation and oxidative stress

Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxy fatty acids into diols. Epoxy fatty acids are signaling molecules that are involved in inflammation, regulation of the redox state, blood pressure, and pain perception, among other physiological functions. Downregulation of sEH activity in various cells has been used for the treatment and management of various cardiovascular and neurodegenerative diseases. Thus, sEH inhibition is an emerging target against inflammation, oxidative stress, and their associated diseases. This paper discusses recent advances and future perspectives in sEH inhibition by extracts and compounds from food sources, including polyphenols, protein hydrolysates and peptides, protoalkaloids, triterpenoids, and fatty acids.

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来源期刊

Current Opinion in Food Science Agricultural and Biological Sciences-Food Science

CiteScore

18.40

自引率

4.00%

发文量

157

审稿时长

92 days

期刊介绍： Current Opinion in Food Science specifically provides expert views on current advances in food science in a clear and readable format. It also evaluates the most noteworthy papers from original publications, annotated by experts. Key Features: Expert Views on Current Advances: Clear and readable insights from experts in the field regarding current advances in food science. Evaluation of Noteworthy Papers: Annotated evaluations of the most interesting papers from the extensive array of original publications. Themed Sections: The subject of food science is divided into themed sections, each reviewed once a year.