通过囊胚补体用人类干细胞生产人类肝脏

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL
Boyukkhanim Ahmadzada , Philipp Felgendreff , Anna M. Minshew , Bruce P. Amiot , Scott L. Nyberg
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引用次数: 0

摘要

器官移植的需求超过了器官捐献的可用性。在解决器官移植短缺问题的过程中,最显著的进步是通过使用嵌合胚胎(通常称为囊胚互补)生产器官。这种技术是将不同的物种结合在一起生成嵌合体,可以调节供体细胞对所需组织或器官的贡献程度。然而,在这种嵌合体中使用脑组织会引起伦理问题。此外,在与细胞凋亡有关的嵌合体生产中,嵌合体系统中供体细胞与宿主动物细胞的比例较低。本综述讨论了囊胚补体的最新创新,并重点介绍了在制造移植器官方面取得的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Producing human livers from human stem cells via blastocyst complementation

The need for organ transplants exceeds donor organ availability. In the quest to solve this shortage, the most remarkable area of advancement is organ production through the use of chimeric embryos, commonly known as blastocyst complementation. This technique involves the combination of different species to generate chimeras, where the extent of donor cell contribution to the desired tissue or organ can be regulated. However, ethical concerns arise with the use of brain tissue in such chimeras. Furthermore, the ratio of contributed cells to host animal cells in the chimeric system is low in the production of chimeras associated with cell apoptosis. This review discusses the latest innovations in blastocyst complementation and highlights the progress made in creating organs for transplant.

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来源期刊
Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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