含有增粘剂的聚阴离子复合囊泡，用于持续释放水溶性低分子量药物

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-05-01 DOI:10.1093/chemle/upae070

A. Goto, Y. Anraku, Shigeto Fukushima, Akihiro Kishimura

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引用次数: 0

摘要

多离子复合囊泡 (PICsomes) 具有多种特性，使其适合用作药物输送系统。然而，由于水溶性低分子量化合物（WLMWCs）囊膜的高渗透性，保留它们仍然是一项挑战。在此，我们提出了一种新方法，通过添加羟丙基甲基纤维素来增加内水相的粘度，从而延长 WLMWCs 在 PICsomes 中的保留和持续释放时间。根据一阶动力学，PICsomes 可保留 2% 至 4% 的 WLMWCs，并且在 96 小时内释放了 100% 的 WLMWCs。

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Polyion complex vesicles containing viscosity enhancer for sustained release of water-soluble low-molecular-weight drugs

Polyion complex vesicles (PICsomes) possess several features that render them as suitable for drug delivery systems. However, retaining water-soluble low-molecular-weight compounds (WLMWCs) remains challenging because of the high permeability of their vesicular membranes. Herein, we propose a new approach for prolonged retention and sustained release of WLMWCs from PICsomes by loading hydroxypropyl methylcellulose to increase the viscosity of the inner aqueous phase. The PICsomes retained 2% to 4% of the WLMWCs, and 100% of the WLMWCs were released within 96 h according to first-order kinetics.

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来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry