Caine C. Smith , Julia Stevens , Mario Novelli, Dhiraj Maskey, Greg T. Sutherland
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引用次数: 0
摘要
磷脂酰乙醇（PEth）是一种酒精衍生物，已被用作定期饮酒的血液生物标志物。本研究调查了磷脂酰乙醇（PEth）作为生物标志物评估死后脑组织中酒精消耗量的实用性。我们利用新南威尔士脑组织资源中心（New South Wales Brain Tissue Resource Centre）的样本，分析了小脑和脑膜中的磷脂酰乙醇（PEth(16:0/18:1)）水平。我们的研究结果表明，PEth 水平与死亡时的血液酒精含量（BAC）之间存在明显的相关性，这证明了该生物标志物对近期酒精摄入量的敏感性。此外，考虑到死后诊断 AUD 的复杂性，本研究还探讨了 PEth 水平在区分 AUD 病例和对照组方面的潜力。研究还探讨了 PEth 水平与肝脏病理之间的关系，确定了 PEth 与肝脏损伤严重程度之间的联系。这些结果凸显了 PEth 作为酒精消耗量可靠指标的价值，以及其对尸检诊断和酒精相关脑损伤研究的潜在贡献。
Phosphatidylethanol in post-mortem brain: Correlation with blood alcohol concentration and alcohol use disorder
Phosphatidylethanol (PEth) is an alcohol derivative that has been employed as a blood-based biomarker for regular alcohol use. This study investigates the utility of phosphatidylethanol (PEth) as a biomarker for assessing alcohol consumption in post-mortem brain tissue. Using samples from the New South Wales Brain Tissue Resource Centre, we analysed PEth(16:0/18:1) levels in the cerebellum and meninges of individuals with varying histories of alcohol use, including those diagnosed with alcohol use disorder (AUD) and controls. Our findings demonstrate a significant correlation between PEth levels and blood alcohol content (BAC) at the time of death, supporting the biomarker's sensitivity to recent alcohol intake. Furthermore, this study explores the potential of PEth levels in differentiating AUD cases from controls, taking into consideration the complexities of diagnosing AUD post-mortem. The study also examined the relationship between PEth levels and liver pathology, identifying a link with the severity of liver damage. These results underscore the value of PEth as a reliable indicator of alcohol consumption and its potential contributions to post-mortem diagnostics and consequently, research into alcohol-related brain damage.
期刊介绍：
Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects.
Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.
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